PAPER Sabbagh MN, Reid RT, Hansen LA, Alford M, Thal LJ

Correlation of nicotinic receptor binding with clinical and neuropathological changes in Alzheimer's disease and dementia with Lewy bodies.

J Neural Transm. 2001 Oct;108(10):1149-57. PubMed.

PAPER Kim KW, Jhoo JH, Lee JH, Lee KU, Lee DY, Youn JC, Youn JY, Woo JI

Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans.

J Neural Transm. 2001 Oct;108(10):1159-66. PubMed.

PAPER Kogan EA, Korczyn AD, Virchovsky RG, Klimovizky SS, Treves TA, Neufeld MY

EEG changes during long-term treatment with donepezil in Alzheimer's disease patients.

J Neural Transm. 2001 Oct;108(10):1167-73. PubMed.

Rajiv Ratan on Is It the Curry?

COMMENT I liked the paper very much. It is generally well done and suggests an easy intervention that could reduce AD onset or progression without significant toxicity. Among the questions it raises are: 1.) How does the concentration of curcumin that is effectiv

Is It the Curry?

RESEARCH NEWS 2001-11-01 Research News In India, the prevalence of Alzheimer's disease among 70- to 79-year-olds is 4.4-fold less than that of the United States. Could they have one of the curry spices to thank for that? So suggest Greg Cole, Giselle Lim, and colleagues at t

Understanding the Role of Estrogen in Cerebral Blood Flow

RESEARCH NEWS 2001-11-01 Research News Estrogen influences a seemingly endless list of physiological processes, among them blood circulation. Indeed, enhanced blood flow to critical areas of the brain is one candidate hypothesis for why estrogen replacement therapy appears to pro

Shining Light on Proteins Touching

RESEARCH NEWS 2001-10-31 Research News A better understanding of precisely how AβPP is processed to generate the Aβ peptide and other, poorly understood proteolytic products has become a priority in Alzheimer's research. In the November 1 Journal of Neuroscience, Ayae Kinosh

Why Do Only Some Neurons Die in Parkinson's?

RESEARCH NEWS 2001-10-31 Research News In Parkinson's disease, as in Alzheimer's, it remains unclear why only a subset of neurons is affected. A report in tomorrow's Journal of Neuroscience now suggests that, in PD, the reason for that specificity may lie in immune

α-Synuclein Aggregation Prevented by β-Homolog

RESEARCH NEWS 2001-10-30 Research News α-synuclein is one of the major proteins found in Lewy bodies (LBs), the cytoplasmic inclusions that pepper the neurons of patients suffering from one of several neurodegenerative diseases, including Parkinson's, Alzheimer's, and d

Modeling Polyglutamine Diseases in Yeast Provides Support for Histone Deacetylase Connection

RESEARCH NEWS 2001-10-30 Research News Never mind that the lowly yeast has no brain. It nevertheless makes a good model for studying the cellular pathology of-and screening for drugs against-polyglutamine expansion diseases such as Huntington's, claim researchers led by Robe

New Gene for Hereditary Spastic Paraplegia Found

RESEARCH NEWS 2001-10-30 Research News An international team lead by John Fink, University of Michigan, has identified a new gene responsible for hereditary spastic paraplegia (HSP). This disorder, which starts in early childhood and can completely paralyze both legs, has been li

A New Candidate Neuroprotective Mechanism for Estrogen

RESEARCH NEWS 2001-10-29 Research News 29 October 2001. Estrogen replacement therapy may protect postmenopausal women from Alzheimer's disease, according to some epidemiological studies. For example, a recent short trial of high-dose 17β-estradiol found significant improveme

Susceptibility Gene Mapped for Late-Onset Parkinson's Disease?

RESEARCH NEWS 2001-10-26 Research News Scientists at the Icelandic genomics company DeCode Genetics, working with colleagues at the National University Hospital in Reykjavik, have presented at last week's meeting of the American Society for Human Genetics in San Diego a post

γ-Secretase Found to Cleave Receptor Tyrosine Kinase ErbB-4

RESEARCH NEWS 2001-10-25 Research News The ErbB family of cell surface receptors is involved in the transduction of cellular growth and proliferation signals; ErbB-1 and ErbB-2, for example, have been implicated in aggressive forms of breast cancer. In tomorrow's Science Exp

Vast Yet Tiny? Charting the New World of microRNAs

RESEARCH NEWS 2001-10-25 Research News Entire new classes of molecules don't come along every day, so it is worth noting that the classic triumvirate of RNA-mRNA, tRNA, rRNA-has just gotten a baby brother. Three independent research teams are reporting in tomorrow's Sci