344037 RESULTS
COMMENT The Lancet Commission report is an heroic achievement but it was rather selective in the risk factors that it reported and which formed the basis of the widely-cited claim that more than a third of dementia cases might be prevented if all the modifiable r
COMMENT Aducanumab may work because it reduces both insouble and soluble Abeta. However it may be incorrect to believe that the beneficial effect can only be manifest in early or prodromal disease because there is too much damage in more advanced cases. Instead i
COMMENT These findings were was novel to me, and show how the immune system is always surprising us. Systemic inflammation needs to be taken into account when considering cell-based therapy. There are multiple clinical trials planned for treatment of Parkinson’s
COMMENT I met Rahul at a conference for early investigators several years back, and we all found it easy to become his colleague and friend. I was struck by his seemingly boundless energy, intelligence, and creativity. It's difficult for me to process the lo
COMMENT We are watching the approval of aducanumab with interest, given that we had cloned the antibody to evaluate whether a combination with therapeutic ultrasound would be more effective in clearing amyloid and improving cognitive functions in the APP23 mouse
COMMENT We appreciate the insightful comment by Drs. Ezzat and Espay and are grateful that our colleagues noticed an incorrect statement with respect to the MS-based levels of Aβwt1-42, which were indeed lower in mutation carriers as compared to control subjects.
BIOMARKER META ANALYSIS 0.920807786243006 0.85332027485511 0.993632759223626-2.12444191030089 0.0336332086231168 0.780916763617068 0.0174521128326773 Biomarker Comparison Reference: Biom Comparison: 1690066_1690071 Effect Metric: 0.817187218663974 Lower CI: 0.614198269979088
BIOMARKER META ANALYSIS 1.08600298014432 1.00640804232476 1.17189293336525 2.12444191030089 0.0336332086231168 0.780916763617068 0.0174521128326773 Biomarker Comparison Reference: Biom Comparison: 1690071_1690066 Effect Metric: 1.22370979031575 Lower CI: 0.919740812144861 Upp
BIOMARKER META ANALYSIS 0.714080625729401 0.508804910113144 1.00217417306115-1.9474048722161 0.051486214407545 0.850127262945386 0.07445646234272001 Biomarker Comparison Reference: Biom Comparison: 1688861_1688856 Effect Metric: 0.471781221994652 Lower CI: 0.339297317850347 U
BIOMARKER META ANALYSIS 0.78371831774872 0.671658195782634 0.914474662010465-3.09561849035528 0.00196402883257577 0.82598138809943 0.0396157854630288 Biomarker Comparison Reference: Biom Comparison: 1688851_1688841 Effect Metric: 0.633160087276012 Lower CI: 0.535168351646127
BIOMARKER META ANALYSIS 1.12695137424435 1.02899201804784 1.23423639604187 2.57594602982164 0.009996624843615539 Biomarker Comparison Reference: Biom Comparison: 1690111_1690116 Effect Metric: 1.07912816902444 Lower CI: 0.939903593097691 Upper CI: 1.23897558614931 LN Effect
BIOMARKER META ANALYSIS 0.557031834015799 0.501134020827956 0.6191646370253689-10.8449380136028 2.10778696099039E-27 Biomarker Comparison Reference: Biom Comparison: 1698556_1698546 Effect Metric: 0.49581737064644 Lower CI: 0.34539938509004 Upper CI: 0.711740887930836 LN Eff
BIOMARKER META ANALYSIS 0.873621107413619 0.732457289367498 1.04199091250448-1.50252617117738 0.132961274215716 0.841097016886201 0.0187419021578997 Biomarker Comparison Reference: Biom Comparison: 1690076_1690066 Effect Metric: 0.941640112731367 Lower CI: 0.725496777750076 U
BIOMARKER META ANALYSIS 0.8031058780547921 0.738607562981869 0.8732364569383519-5.1332983498799 2.84708045343256E-7 Biomarker Comparison Reference: Biom Comparison: 1698601_1698571 Effect Metric: 0.82503308757113 Lower CI: 0.72391794431763 Upper CI: 0.940271754457979 LN Effe
BIOMARKER META ANALYSIS 0.912651921394621 0.873392421331075 0.953676158943397-4.07422692212433 4.61674494104907E-5 0.794519478430349 0.0177527070492966 Biomarker Comparison Reference: Biom Comparison: 1688891_1688896 Effect Metric: 0.831690493580475 Lower CI: 0.74265364619742
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