Does Cognition Change With the Seasons?
In large cohorts, older people tested in summer and autumn scored higher on cognitive tests than people tested in winter and spring. Is a seasonal clock ticking in the background?
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Model Morass? R47H Mutation Scuttles TREM2 Expression in Mice, Not People
A new finding questions the usefulness of some mouse models.
Exercise Pill? Pharmacological Mimics Boost Cognition in Lazy Mice
Treatments that promote neurogenesis and elevate BDNF act as exercise does to improve memory in mouse models of Alzheimer’s disease.
ALS Mutations Stiffen Profilin, Steer Protein Toward Aggregation
Computational models predict that ALS mutations tax the flexibility of profilin-1, weaken binding with key partners including actin, and boost the protein’s propensity to aggregate.
Tau Stymies Transport Through Neuron’s Nucleus
By yanking a nuclear protein out of its pore, phosphorylated tau makes nuclei leaky, disrupting the strictly controlled passage of proteins and setting tau up for aggregation.
Flortaucipir Meets Primary Endpoints in Phase 3 Autopsy Trial
PET tracer predicts tau pathology and AD, according to company press release.
Does Retinal Thinning Reflect Early Alzheimer’s?
Study links changes in the retina’s microvasculature to brain amyloid in cognitively normal adults.
Let ’Er RIP: ALS/FTD Variant Plus Aging Unleash Deadly Kinase
Loss-of-function mutations in TBK1 combined with age-related dearth of an analog spell trouble for motor neurons and the central nervous system.
Conformers Confirmed: Structure of Pick’s Tau Distinct from AD Tau
A molecular-level view of tau filaments from a person with Pick’s disease reveals that the protein folds up differently than it does in Alzheimer’s disease.
Tiny Passageways Connect Skull Bone Marrow to the Brain
Vascular microchannels linking the skull bone marrow to the dura mater supply the brain with neutrophils in response to stroke and inflammation.
Technology for Patients: Purring Robots, Digital Data-Gathering
AAIC showcased advances in scientists’ attempts to integrate technology into dementia care and research. This includes the use of furry robot seals to keep patients company.
'Organ on a Chip' Models the Ins and Outs of the Blood-Brain Barrier
The microfluidic device could test the vascular contributions to neurodegenerative disease and bioavailability of drugs for the brain.
For the Faint of Heart: Doc, Want to Check Their NfL?
What's the use of measuring neurofilament light in blood? The marker could help with AD trial enrollment and measuring drug effects. It could even guide brain-sparing improvements in heart surgery, say researchers at AAIC 18.
Blood Test for Neurofilament Light Chain Kicks Up Biomarker Research
With buckets of new data at AAIC, blood NfL grabbed attention as a telltale of neurodegeneration. The protein predicts progression, and might one day track treatment effects.
Treating ALS in a Dish? Models Point to Drug Candidate for Sporadic Disease
The dopamine receptor agonist ropinirole emerged as the top hit in a screen of induced motor neurons.
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