Senate Approves $2.34 Billion Budget for Alzheimer’s Research
The 2019 budget ups this year’s spending by $425 million.
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Brain-Wave Patterns Distinguish Parkinson’s Subtypes
Neural-wave patterns could help clinicians guide electrodes for deep-brain stimulation.
Tangles Turn Neuronal Membranes Inside Out, Give Microglia License to Eat Their Fill
Tau-laden neurons present a phospholipid “eat me” signal, bidding microglia to devour them alive.
Brain Damage from Cardiovascular Disease Starts Earlier Than You Think
Data from two independent cohorts suggest that the risk to the brain from high blood pressure and cardiovascular disease begins in a person’s 40s or before.
With Sudden Progress, Blood Aβ Rivals PET at Detecting Amyloid
At AAIC, competitors vied for advantage, and discussion moved swiftly to the issue of assay standardization.
Estrogen’s Benefit Tied to Age: Good for the Young, Bad for the Old
Greater lifetime estrogen exposure protects cognition, while hormone replacement therapy taken at menopause has no cognitive effects at all.
Do Brain Changes at Menopause Make Women More Prone to Alzheimer’s?
At AAIC, scientists said that alterations in how the aging female brain uses energy and metabolizes fat may leave APOE4 carriers particularly susceptible to tau pathology.
Weeklong Chinese Challenge Reveals Subtle Memory Problems
At AAIC, technology improves on pen-and-paper tests of early cognitive decline. Think learning Chinese, think smartphone burst, think digital clock.
Surprise: HDAC Goes Down, Not Up, in Alzheimer’s Disease
A new PET tracer belies previous results from animal models and postmortem studies. Caveat emptor for trials of HDAC inhibitors?
Memory Slips as Soon as Amyloid Appears, Two Decades Before Dementia
Sensitive cognitive tests detect deficits in preclinical Alzheimer’s even before an amyloid scan reads positive. And CSF Aβ42 drops a decade before that—pushing research ever farther into the preclinical phase.
Four Immunotherapies Now Banish Amyloid From the Brain
New data from gantenerumab and N3pG confirm that high-dose antibodies clear plaque dramatically, with manageable side effects. How will the aging brain respond?
In C9ORF72 Expansion Carriers, Protein Levels Drop in Cerebellum
A batch of new monoclonal antibodies against the C9ORF72 protein also revealed the protein lingers in presynapses.
Largest AD Whole-Exome Study to Date Finds Two New Risk Genes
A zinc-finger protein and a long noncoding RNA are now implicated in late-onset Alzheimer’s disease.
Thinning Retina … Could It Be Parkinson’s?
In early Parkinson’s disease, sparse areas on the retina correlate with dying dopaminergic neurons in the substantia nigra.
FDA Approves First RNAi Therapy
The drug, patisiran, targets messenger RNAs that cause transthyretin amyloidosis, a rare inherited neurodegenerative disease. Approval paves the way for other RNAi-based therapies.
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