ApoE: Common Microglial Culprit in Aging, Alzheimer’s, and Tauopathy?
Translatome profiling suggests ApoE drives a microglial gene-expression signature found in aging, Aβ amyloidosis, and tauopathy.
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Donepezil Not the Answer for Depressed MCI Patients
The acetylcholinesterase inhibitor failed to slow cognitive decline in people with both depression and mild cognitive impairment.
Focused Ultrasound Breaches Blood-Brain Barrier in People with Alzheimer’s
Data from the first human study hints the procedure could help deliver drugs to the brain, or even work as a therapy in its own right. A flurry of animal studies presented at AAIC support the idea.
No Mutation Required? Cell Stress Goads Aggregation of Wild-Type SOD1
In mice, aggregates of oxidized SOD1 accumulated with age, and endoplasmic reticulum stress made it worse. Does this explain SOD1 aggregates found in spinal cords of patients with sporadic ALS?
Alzheimer’s Disease-Related Proteins Needed for Neurogenesis
The hippocampus trickles out new neurons throughout life, a process that falters without BACE1 or in the presence of ApoE4.
Could Better Blood Pressure Management Preserve Cognition?
In SPRINT MIND trial, strict control of systolic pressure slashed MCI incidence by almost 20 percent.
PET Ligand Lights Up AAIC, May Detect Synapse Loss in AD
UCB-J hints at early synaptic loss in the hippocampus, but not the cortex. Researchers puzzle over the pattern.
On Target: Crenezumab Reduces Aβ Oligomers in CSF
Analyzing Phase 2 trial CSF of an investigational immunotherapy, scientists showed for the first time that treatment mitigates neurotoxic oligomers in patients.
Lymphatic Brain Drain Withers in Aging, Worsens Disease
Aging lymphatic vessels in the meninges hinder waste clearance from the brain and exacerbate Aβ build-up.
Osmotic Stress Ushers FUS Out of Nucleus and Into Stress Granules
The findings offer one way this RNA-binding protein gets into cytoplasm, where it sets the stage for pathological aggregation.
Alzheimer's Association International Conference 2018
BAN2401 Removes Brain Amyloid, Possibly Slows Cognitive Decline On Target: Crenezumab Reduces Aβ Oligomers in CSF PET Ligand Lights Up AAIC, May Detect Synapse Loss in AD Could Better Blood Pressure Management Preserve Cognition? Focused Ultrasound Breach
BAN2401 Removes Brain Amyloid, Possibly Slows Cognitive Decline
Researchers consider the data encouraging, though questions linger about the cognition results. Did regulators mess up the randomization of this trial?
Jumping Genes Rampant in Tau Flies
By loosening their chromatin straitjackets, and reining in their RNA watchdogs, tau unleashes transposable elements into the genome.
$30 Million Venture Philanthropy Project for AD Biomarkers
Investors pledge new money for research into biomarkers that yield marketable tests.
Next-Gen Antisense and Small Protein-Protein Disruptors Benefit SOD1 Models
Oligonucleotides that suppress SOD1, and small molecules that limit its binding to the protein Derlin-1, delay disease onset and extend lifespan in rodent models of ALS.
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