Courtesy of CryoEM: GABAA Receptor in Close-Up View
Get up close and personal with the GABAA receptor, a key mediator of inhibitory signaling in the brain and a drug target in a wide range of disorders, including Alzheimer’s.
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In New ALS/FTD Mouse Model, Poly(GR) Peptides Poison Ribosomes
Chronic inhibition of protein synthesis, and slowing the dispersal of stress granules, contribute to neurodegeneration in C9ORF72 ALS/FTD.
Packets of Neuronal Aβ42 Spotted in the Presynapse
In healthy neurons, small vesicles at the presynapse and larger ones in neurites harbor Aβ42, according to super-resolution microscopy.
Girl Power? In Mice, Female Microglia Protect Against Ischemic Injury
Males are inflammatory, females are neuroprotective: Profiling of microglia from adult mice suggests sex-specific phenotypes, likely set at birth.
α-Synuclein Antibody Appears Safe, Reaches Brain
Roche and Prothena publish Phase 1b results for their antibody PRX002/RG7935.
Aberrant Networks in Alzheimer’s Tied to Herpes Viruses
Big data analyses correlate viral load with clinical, molecular, and pathological features of AD. Time to consider the pathogen hypothesis anew?
Blood Pressure Affects Dementia Risk Only in People Under 60
A large epidemiological study better defines the risk from hypertension. This may sharpen recommendations for prevention.
In Human Neurons, ApoE4 Promotes Aβ Production and Tau Phosphorylation
Two papers report that the ApoE4 allele triggers both hallmarks of AD in iPSC-derived cultures, in contrast to its minimal effects in mouse neurons.
Synaptojanin 1 Gene Affects Age of Onset in Familial AD, Memory in Mice
Overexpression of synaptojanin 1 leads to hippocampal place cell dysfunction in mice. Could it contribute to memory problems in AD?
For One in Four Memory Clinic Patients, Amyloid-PET Changes the Diagnosis
In an unselected cohort, amyloid-PET scans changed clinical diagnoses and treatment plans for a quarter of participants.
Does Taming Killer Astrocytes Spare Neurons in Parkinson’s Disease?
Study suggests a diabetes drug under investigation for both Parkinson’s and Alzheimer’s diseases acts by quieting microglia and shutting down the pathological activation of astrocytes.
Scratch Lanabecestat: This BACE Inhibitor Doesn’t Work in Symptomatic AD, Either
After veru- and atabecestat, now a third β-secretase inhibitor, by Eli Lilly and AstraZeneca, is being pulled from ongoing Phase 3 trials of symptomatic Alzheimer’s disease.
Dipeptide Repeats May Hobble Ribosomes in C9ORF72-FTD Patient Brain
Though the dipeptides interacted with many proteins in cell culture, they associated specifically with ribosomes in the human brain.
Antisense Oligonucleotides Turn Down the Aβ Spigot
In mice, antisense oligonucleotides that splice out more than half of the Aβ peptide drive down its levels in the brain.
Tau Aggregates Awaken Genetic Relics in the Brain
By prying open chromatin, neurofibrillary tau may expose dormant transposable elements for transcription.
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