Liver Tox Ends Janssen BACE Program
The company has halted all trials of atabecestat.
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“Nanosweeper” Brushes Aβ into Cellular Dustbins
Engineered nanoparticles snatched extracellular Aβ, ferried it into cells, and switched on autophagy, clearing the peptide from the brains of mice. Would this work as a drug?
No, TDP-43 and FUS Are Not Actively Exported From the Nucleus
Contrary to previous findings, both proteins seem to escape via passive diffusion. This has implications for therapeutic strategies to keep them where they belong.
Oligodendrocytes Seem to Imprint Specific Alter Ego on α-Synuclein
Aggregates that form inside, or just pass through, oligodendrocytes take on the properties of the virulent strain that gives rise to multiple system atrophy.
Study Finds Sex Influences CSF Tau Levels in ApoE4 Carriers
ApoE4 raises CSF tau more in women than in men, suggesting sex may influence the risk of neurodegeneration, especially in amyloid-positive E4 carriers.
Cholesterol Greases the Aβ Aggregation Machine
Exposure to lipid membranes embedded with cholesterol accelerate Aβ fibril formation by up to 20-fold.
Do Mild Traumatic Brain Injuries Double the Risk of Dementia?
A large retrospective study in veterans finds that even brain injuries that cause no loss of consciousness come with a twofold higher risk of developing all-cause dementia.
Japanese ADNI Data Parallel North American ADNI, Encouraging Global Trials
The two datasets reveal almost identical cognitive decline in prodromal AD, the stage targeted by secondary prevention trials.
A Little Amyloid, A Lot of Trouble?
Even at below threshold levels, cortical amyloid can drive cognitive decline, tau accumulation.
Move Over, Flortaucipir? New Tau Tracers Tested in People
Two tau PET tracers flag brain areas that accumulate tangles, without background labeling in the choroid plexus. However, pesky off-target binding was seen in the meninges.
Small Molecule Keeps Mutant SOD1 Out of Trouble
The antioxidant ebselen promotes disulfides in SOD1, restores dimerization, and prevents protein misfolding.
New Alzheimer’s and Parkinson’s Immunotherapy Data at AAN
Biogen showed results from clinical trials of anti-Aβ and anti-α-synuclein antibodies at the American Academy of Neurology annual meeting.
In Mice, CRISPR-Based Alzheimer’s Therapies Inch Forward
Researchers take first steps on road to targeting disease-causing APP mutations and amyloid processing.
Paper Alert: Verubecestat EPOCH Findings Published
The drug had no effect on any clinical measure, while there were side effects such as rashes, insomnia, and thoughts of suicide.
Loss of Soothing Lipids in AD Brain Furthers Microglial Mayhem
In an AD mouse model, a deficit in specialized mediators prevented microglia from tempering inflammation and clearing Aβ. Time to learn about resolvins?
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