Even Mild Traumatic Brain Injuries Raise Risk for Dementia, Parkinson’s
Two enormous epidemiological studies strengthen the link between head injuries and neurodegenerative disease.
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Treat IBD, Dodge PD? Epidemiology Ties Parkinson’s to Inflammation
People with inflammatory bowel disease are at higher risk for Parkinson’s—but not if they take anti-inflammatory medication.
JAD Turns 20 with Open-Access Special Issue
Thirty-five reviews cover two decades of Alzheimer’s research.
GWAS, GWAX: bioRχiv Hosts Bonanza of Alzheimer’s Genetics
Three genome-wide association studies, including the largest-ever thanks to UK Biobank, reveal 13 new AD risk loci. They implicate APP processing in LOAD, and further highlight inflammation and lipid metabolism.
Liquid Phase Transition: A Deluge of Data Points to Multiple Regulators
Transportins, methylation, and RNA all regulate LLPS and the behavior of pathogenic RNA-binding proteins.
Will PET Tracer, Monkey Model, Finally Bulk Up Toolbox for Parkinson’s?
At AAT-AD/PD, scientists said an α-synuclein PET tracer is headed into trials. And marmosets model PD behaviors better than rodents. (Spoiler alert: They kick their partners while they sleep.)
Stuck in the Past? Microglial Memories Dictate Response to Aβ
Systemic inflammation can alter the epigenome of microglia, dictating whether the cells clean up Aβ pathology, or exacerbate it.
Genetics Tie ALS into the Frontotemporal Dementia Spectrum
Massive meta-analysis finds no link with AD or PD.
Does Amyloid Accumulate After a Single Sleepless Night?
Volunteers kept awake all night retained more florbetaben in their hippocampi and thalami in morning-after PET scan.
Do Immune Responses Promote, or Prevent, Parkinson’s Disease?
In animal models, a PD risk gene revs up the immune system to fight infections, while probiotic bacteria slow α-synuclein aggregation.
Parkinson’s Treatments Go After Genetic Targets
Researchers at AAT-AD/PD discussed investigational PD treatments that aim to modify disease by hitting genetic risk factors.
New Definition of Alzheimer’s Hinges on Biology, Not Symptoms
For the first time, NIA-AA proposal bases diagnosis in living people solely on biomarkers for plaques and tangles.
Is Shape of Aβ an Early Blood Biomarker for Alzheimer’s?
An infrared spectral signature of amyloid β-sheets predicted AD conversion years before diagnosis.
Newborn Neurons in the Adult Brain: Real Deal, or Glial Imposters?
A study reported that new neurons continue to sprout from the human hippocampus well into the golden years, while another claims they all but disappear after childhood.
Alzheimer’s Incidence is Rising, Not Falling, a Researcher Says
A widely popularized finding of shrinking dementia rates is entirely due to less vascular dementia, and is in fact concealing a rise in AD and PD, according to a provocative talk at AAT-AD/PD.
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