Tracking LRRK2-Parkinson’s Progression for Better Trial Design
A large, prospective study confirms that PD unfolds more slowly in people with the G2019S LRRK2 mutation. The data will help scientists design and interpret clinical trials.
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New TDP-43 Knock-In Mice: A Model for Frontotemporal Dementia?
The knock-ins had no motor deficits or TDP-43 cytoplasmic inclusion. Instead, the animals had FTD-like behavioral problems.
New RNA CRISPR Tool Normalizes Tau Splicing
A family of petite, RNA-directed nucleases offers a platform for finessing the transcriptome.
David Bennett Wins 2018 Potamkin Prize
Rush University researcher recognized for longitudinal studies on aging, memory, and dementia.
Does Daytime Drowsiness Foreshadow Aβ Accumulation?
Researchers report a link between sleepiness and accelerated Aβ buildup in the cingulate and precuneus of elderly adults without dementia.
So Far, So Good for Parkinson’s Gene Therapy
Voyager Therapeutics announced positive interim results from a small, ongoing Phase 1b trial in people with advanced PD.
Compact Mouse Brain Atlas: A New Tool for Studying Neurodegeneration?
Representing each cell as a point, the atlas could help scientists measure brain-wide cell numbers and activity in health and disease.
TREM2 Binds Aβ, Reprograms Microglia to Curb Plaques
Two new papers strengthen the evidence that TREM2 protects against amyloid pathology.
Big Data Was the Big Theme at Shortened NIH Summit
A winter storm cut the meeting short, but not before attendees learned that viral load correlates with clinical and pathological traits of AD.
CRISPR Screen Pulls Down Fresh Targets for C9ORF72 ALS
A CRISPR knockout screen in human cells and mouse neurons found genes that tweak C9ORF72 toxicity, zeroing in on ER stress as a potential therapeutic target.
Remember: BACE2 Is in the Brain, Too
After verubecestat’s demise, scientists ask if BACE inhibitor side effects could partly stem from the other BACE.
Wiping Out Microglia Prevents Neuritic Plaques
In transgenic mice, killing off microglia with the CSF1R inhibitor PLX3397 prevented accumulation of intraneuronal Aβ, neuritic plaques.
De Strooper, Goedert, Hardy, Haass Share 2018 Brain Prize
World’s biggest brain research award goes to European leaders on Aβ tau and TREM2.
Parental Age of Onset Helps Predict Amyloid Accumulation in Sporadic AD, Too
In three independent cohorts, cognitively healthy people had a higher amyloid burden as they approached the age at which their parents developed late-onset AD.
In TDP-43 Mouse, Hesitant Microglia Eventually Swoop to the Rescue
When neurons stop making mutant TDP-43, microglia alter their transcription profiles, clear aggregates, and help restore motor function.
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