Are Reversible Amyloids Behind Liquid-Liquid Phase Separation?
Newly found labile cross-β filament structures may mediate multivalent protein interactions among low-complexity domains.
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Microglial Transcriptome Hints at Shortcomings of AD Model
A meta-analysis confirms microglial phenotypes associated with neurodegeneration, but highlights differences between human and mouse.
Can Closed-Loop Brain Stimulation Improve Memory?
Researchers improve word recall by jolting the lateral temporal cortex, claiming this counters firing patterns linked to poor memorization.
Faulty Brain Clocks Precede Alzheimer’s, May Drive Pathology
Healthy people with Aβ buildup have irregular circadian rhythms. In mice, circadian disruptions dull daily Aβ oscillations and lead to more plaques.
Merck Axes Verubecestat for Prodromal AD, Researchers Say ‘Go Earlier’
The Phase 3 APECS trial of Merck’s flagship BACE inhibitor ends prematurely following an interim safety analysis.
In Familial Alzheimer’s, Tau Creeps into Cortex as Symptoms Show
In people with an autosomal-dominant AD mutation, Aβ and tau start accumulating long before the estimated onset of symptoms.
Loss of Pericytes Wreaks Havoc in Mouse Brain
Knocking down these capillary-hugging cells triggers a domino effect; blood proteins invade the brain, white matter deteriorates, and neurons die.
Lack of C9ORF72 Protein Renders Neurons More Vulnerable to Degeneration
A new study provides the first solid evidence for a loss-of-function mechanism in ALS caused by C9ORF72 repeat expansions.
Imaging Clinches Causal Connections between Aβ, Tau, Circuitry, and Cognition
In cognitively normal people with Aβ accumulation, tau pathology tracked along neurons from the hippocampus into the cortex and associated with poorer memory.
Astrocytic IL-33 Signals Microglia to Engulf Synapses
Crosstalk between different glia controls wiring in the developing brain.
Tau Uses Synaptogyrin-3 to Clump Synaptic Vesicles
Pathological forms of tau wander into presynaptic terminals, where they bind synaptogyrin-3. This cross-links synaptic vesicles, and mayhem ensues.
Cancer and Neurodegeneration: Flip Sides of a Coin
Both problems affect similar genes, but their expression changes in opposite directions.
Closing in on a Blood Test for Alzheimer’s?
A Japanese company enters the arena with a plasma Aβ test that rivals CSF for detecting brain amyloid.
No Amyloid, No Memory Problem—Even with ApoE4?
In AIBL, memory declines as people with brain amyloid age. Without amyloid, episodic memory keeps steady, even in ApoE4 carriers.
Are ALS Dipeptide Repeat Ribbons Entangling Proteasomes?
Cryoelectron tomography yields pictures suggesting that poly-Gly-Ala peptide repeats form proteasome-trapping ribbons inside neurons.
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