DLB: Intepirdine a No-Go, Nelotanserin Shrouded in Controversy
Initial report touted positive exploratory results for nelotanserin, but a correction wiped out optimism.
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RIP: Serotonin Receptor 5-HT6 Antagonist
Publication of negative results of Phase 3 idalopirdine trials lays to rest yet another candidate drug.
Antibody Shuttle Rouses Anti-Aβ Response in Brain without Waking the Periphery
An anti-Aβ antibody holding a transferrin ticket to the brain stokes an immune response against Aβ, but not against the transport system.
New Microglial Model May Aid Genetic Studies, Drug Screening
Microglia-like cells from blood monocytes facilitate large-scale studies.
Turning Peripheral Stem Cells into Amyloid-Gobbling Brain Phagocytes
Screen identifies antibody that induces mouse bone marrow cells to differentiate and travel to the brain, where they clear plaques.
Field Loses Beloved Wizard of Glia, Ben Barres, 63
Pancreatic cancer felled the man who led groundbreaking research on astrocytes, oligodendrocytes, and microglia.
2017—A Year in Research
The Alzforum team compiles some of their favorite stories from the past year.
No Man’s Land: Neither Early Success nor Failure for BAN2401
Bayesian adaptive Phase 2 trial of anti-protofibril Aβ antibody did not, as desired, deliver an accelerated result. It will now continue to its end at 18 months.
Is There No End to Tau’s Toxic Tricks?
At SfN 2017, some of the lesser-known tau toxicities came in for deep scrutiny.
Gut Microbiome May Modify Neurodegeneration
At SfN 2017, scientists advanced the idea that bacteria teeming in a person’s digestive tract could influence both pathology and symptoms of diseases such as Alzheimer’s.
Disturbed Sleep Exerts Toll on Memory and Neurodegeneration
Why, hello tau! Convergence of PET and EEG research affirms that sleeping well is crucial to memory consolidation and curbing Alzheimer’s-related proteins.
Society for Neuroscience Annual Meeting 2017
Tau Snapshots from Neuroscience 2017 Disturbed Sleep Exerts Toll on Memory and Neurodegeneration Gut Microbiome May Modify Neurodegeneration Is There No End to Tau’s Toxic Tricks? This year’s annual meeting drew more than 23,000 scientists and featured 1,
Tau Snapshots from Neuroscience 2017
Novel ways to control tau captured the imaginations of scientists at the Society for Neuroscience annual meeting.
Gene Editing Delays Disease Onset in ALS Model Mice
Using CRISPR for the first time in a model of ALS, researchers dampened expression of mutant SOD1 in mouse motor neurons
Do Microglia Spread Aβ Plaques?
Protein bundles released by microglia, called ASC specks, seed Aβ aggregates in vitro and in vivo.
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