How Does a Neuron Avoid Aggregation of Liquid Protein Droplets?
Mutations spur fibrillization, while methylation and autophagy keep droplets nice and fluid.
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BACE Block Nips New Plaques in the Bud, Old Ones Keep Growing
Pinching the Aβ spigot with BACE1 inhibition doesn’t shrink plaques. It does slow their growth and stops new ones from forming. Is that going to be good enough?
Hot in Here? Or Is it Just My Mitochondria?
Using a new fluorescent sensor, researchers recorded temperatures close to 50°C in these cellular energy plants.
There’s No Tomorrow for TOMMORROW
The trial’s sponsor announced an early end to the large Alzheimer’s prevention study based on an interim futility analysis.
Parkinson’s Risk Genes Add Up to Hasten Disease
The more risk variants in a person’s genome, the faster they decline on both cognitive and motor tests.
End of the EXPEDITION: Solanezumab Results Published
Antibody comes close, but can’t slow mild AD.
Scanning Top 20 GWAS Hits for Amyloidosis: Slim Pickings
In ADNI, only a handful of variants associate with amyloid PET. Their impact may vary by disease stage.
Stressed-Out Cells Translate C9ORF72 Repeats, Unleash Toxic Peptides
Three new studies agree that cellular stress favors noncanonical translation of dipeptide repeats from an intron in the C9ORF72 gene, but diverge on the exact mechanism.
Gut Immune Cells, not Blood Pressure, Blamed for Salt’s Effect on Brain
Scientists elucidate a new pathway by which salt triggers adaptive immune cell responses in the gut, which harm memory without driving up blood pressure.
Skimping on Sleep Makes For More Aβ in the Brain
A pilot study finds that depriving people of sleep bumps up their nightly Aβ production.
New Mouse Models Reveal Unexpected Property of TREM2
The shed domain of this microglia receptor sticks to plaques and neurons. Not so for the R47H AD variant, however.
New Genetic Variants Associated with Brain Imaging Traits
Using whole-genome sequence analysis, researchers find genetic variants linked to white-matter integrity, and cerebral and hippocampal volume.
TDP-43 Snarls Nuclear Traffic
A new protein-labeling technique puts TDP-43 on the growing list of neurodegeneration-associated proteins that displace nucleoporins and nuclear transport factors.
Memory Slips in Amyloid-Positive People, but by Itself Cannot Foretell AD
Though memory scores were more likely to slide in cognitively normal people who tested positive for brain amyloid deposition, this decline alone was unable to predict early Alzheimer’s disease.
Genetic Findings Link Parkinson’s to Crohn’s Disease, Inflammation
Multiple variants in and around the LRRK2 gene raise or lower risk for both diseases together, hinting at similar underlying mechanisms.
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