Antisense Therapy Cuts Huntingtin Protein in CSF by Half
Ionis Pharmaceuticals reported positive top-line data from the Phase 1/2a trial of its ASO.
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FUS Helps miRNA Silence Genes. For ALS, What Does It Mean?
Scientists found FUS interacts with Argonaute, miRNAs, and targets mRNAs to quell gene expression.
Are Intraneuronal Aβ Oligomers ‘Seeding Units’ of Alzheimer’s Disease?
In neuronal cell culture, extracts from AD mouse brain seeded intracellular clumps of Aβ oligomers. Like prions, the inclusions persisted through generations of cells.
FDA OKs Cognition as Sole Outcome Measure for Preclinical AD Trials
The agency is accepting comments on a draft guidance that updates its recommendations for early AD trials, as well as on its first-ever guidance for ALS drug development.
When Neurons Get Excited, They Spill α-Synuclein
Activity-dependent secretion accounts for majority of extracellular α-synuclein in brains of healthy mice.
Can Aβ Seeds Be Transferred During Neurosurgery?
Researchers claim that young cases of cerebral amyloid angiopathy may have been caused by contaminated surgical equipment.
Is Alcohol Abuse a Bigger Dementia Risk Than We Thought?
Health records from 31 million French people suggest that drinking to excess is a major risk factor for early onset dementia.
Aβ, Then Metabolism, Then Atrophy: In Familial AD, Cascade is Definitive
Longitudinal neuroimaging of DIAN participants reveals that in most regions of the brain affected by AD pathology, Aβ accumulates first, then metabolism slows, then the brain shrinks.
Boehringer Ingelheim Bails on Candidate Alzheimer’s Drug
The PDE9A inhibitor BI 409306 failed to improve cognition in Phase 2 trials.
Citrullination, Anyone? New Gene Implicated in ALS
A variant squelching expression of PAD4 enzyme reportedly drives up ALS risk by reducing aggregation of RNA-binding proteins.
Pimavanserin Phase 2 Trial Data Published
First presented at CTAD 2017, results suggest good safety, hint at efficacy for this serotonin-targeted drug.
Chan Zuckerberg Initiative Seeks Collaborators for Basic Research in Neurodegeneration
Its Challenge Network seeks to attract new investigators and new ideas to focus on cross-disease cell biology.
Jacques Nunez, Tau Pioneer, Dies at 90
The French biochemist was part of the team that identified tau as the major component of neurofibrillary tangles in 1985.
BACE1 Conditional Knockouts Model Adult BACE Inhibition
Researchers claim that amyloid deposits completely vanish when BACE1 expression is gradually shut down in adult, plaque-ridden mice.
Aged Astrocytes Prime Brain for Neuroinflammation
Two transcriptional profiles of astrocytes in healthy old mice record a surge in reactive and inflammatory gene expression.
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