In ALS, Do Motor Neurons Go Out with a Bang or a Whimper?
Maybe it’s not hyperexcitability, after all. Correlating electrical activity with muscle strength, scientists conclude that motor neurons become hypoexcitable just before degenerating.
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Fighting RAGE No Help to Alzheimer’s Disease Patients
An antagonist to this receptor was trounced in Phase 3 trial.
News From the PET Front: Early Amyloid Networks and Tau Mystery
At AAT-AD/PD, scientists showed that correlated amyloid patches are an even earlier marker than brain-wide positivity, while others puzzled over why tau signals are lower in older people.
Structural Biology Sheds Light on Regulation of Liquid-Liquid Phase Transition
Low complexity and globular domains can promote LLPS, and phosphorylation hampers both.
DIAN and ADNI Data Say Familial and Sporadic AD Converge
A comparison of these large data sets shows that while the two forms of Alzheimer’s disease have separate triggers, they follow the same course and are much more similar than different.
To Block Tau’s Proteopathic Spread, Antibody Must Attack its Mid-Region
The epitope that a therapeutic tau antibody targets determines whether it prevents seeding in cellular assays, raising questions about first-generation antibody trials.
AAT-AD/PD Focus Meeting 2018- Advances in Alzheimer’s and Parkinson’s Therapies
After Plasma Aβ, Now Plasma P-Tau181 Shows Promise To Block Tau’s Proteopathic Spread, Antibody Must Attack its Mid-Region DIAN and ADNI Data Say Familial and Sporadic AD Converge News From the PET Front: Early Amyloid Networks and Tau Mystery Alzheimer’s
After Plasma Aβ, Now Plasma P-Tau181 Shows Promise
Scientists at the AAT-AD/PD conference debuted new detection methods for this biomarker, which they say distinguished healthy controls from MCI and AD.
Human ApoE Antibody Nips Mouse Amyloid in the Bud
This alternative approach to Aβ immunotherapy targets unlipidated, plaque-associated ApoE.
Derived Human Microglia Manage Without Functional TREM2
A new protocol robustly generates microglia-like cells from human stem cells. Disease-causing TREM2 mutations have little effect on some of their innate immune responses.
NGF Gene Therapy Trial Data Published
No benefit detected in double-blind trial with sham surgical controls.
Isotope Labeling Links Tau Production to Aβ Burden
Injecting 13C-labeled leucine intravenously, researchers tracked tau turnover in the human brain and cerebrospinal fluid for the first time.
44-Year Study Ties Midlife Fitness to Lower Dementia Risk
In a small group of Swedish women, the fittest were nearly 90 percent less likely to develop dementia.
Massive ALS GWAS Cements Cytoskeletal Link to Disease
Kinesin mutations may disrupt organelle transport, putting motor neurons at risk.
CSF Markers of Neuronal Injury Drop When Dementia Arrives
What goes up can come down—rising tides of VILIP-1, neurogranin, and SNAP-25 ebb after onset of AD symptoms.
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