Dipeptide Repeat Proteins Trigger TDP-43 Pathology, Faulty Nuclear Import
In a fly model, C9ORF72 pathology pulls TDP-43 from the nucleus, which leads to disrupted nuclear import and neurodegeneration.
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Does APP Promote Synapse Loss, Aβ Production Through Wnt Signaling?
A Wnt pathway inhibitor rescued dendritic spines in cultured neurons and cleared plaques in an AD mouse model.
ALS Gene Tied to Psychiatric and Neurodevelopmental Disease
Families of ALS and FTD patients with C9ORF72 expansions have more mental illness, suggesting the gene affects brain function throughout life.
In Mice, Caspase-1 Inhibitor Quells Inflammation, Aβ, Memory Loss
VX-765 could be a therapeutic candidate for Alzheimer’s disease.
Are Tauopathies Caused by Neuronal and Glial Senescence?
Removing senescent cells from mouse brain ameliorates the effects of mutant human tau.
Nilvadipine Fails to Slow Cognitive Decline in AD Patients
Believed to be an amyloid-lowering agent, the blood pressure drug did not help people at the dementia stage of disease.
$2.34 Billion Alzheimer’s Budget Signed Into Law
The bill tops last year’s budget for the disease by $425 million.
RNA-Binding Protein Linked to Ataxin-2 toxicity
Staufen1 may deplete certain mRNAs, precipitating the death of Purkinje and other neurons.
Exercise Linked to Less Pathology, Better Function in Familial AD
In DIAN, participants who are more physically active may also have slower disease progression.
In DIAN, Serial and Cross-Sectional Biomarker Trajectories Diverge
Serial data establishes different trajectories for CSF t-tau and p-tau.
Flortaucipir Imaging Distinguishes Alzheimer’s From Other Disorders
A large multicenter study confirms the tau PET ligand identifies AD at the dementia stage, but not so well at prodromal stages.
In Conditional BACE1 Knockouts, Hippocampal Axons Compromised
Ablating BACE1 in adult mice spares them from most problems found in germline knockouts. However, axons extending from newborn hippocampal neurons still lose their way.
Does LRRK2 Sweep α-Synuclein from the Cell?
By promoting the exocytosis of cellular debris, the kinase may facilitate spread of α-synuclein aggregates.
Cognitive Deficits Worse with ALS Stage
Neuropsychological impairments are common in amyotrophic lateral sclerosis, even more so for people at late stages of disease.
Lifestyle Coaching Slows Cognitive Decline in African-Americans with MCI
A behavioral intervention slowed memory slippage and functional decline over two years.
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