Too Hot, Too Cold, or Just Wrong? Physiology Links Behavior to Circuits in FTD
Using physiological measurements, researchers are tracing behavior changes in frontotemporal dementia back to crumbling neural circuitry.
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Does Shining Laser Light on Blood Reflect Alzheimer’s?
By beaming red light at a blood sample and measuring the scattered photons, scientists claim to identify people with Alzheimer’s disease.
More Data, More Progress: ALS Researchers Debut Shared Database
Introducing a clinical trials database for ALS that encompasses nearly 9,000 patient records, the organizers tease with the first few findings.
Don’t Smell the Reaper: Waning Olfaction a Harbinger of Death?
People who lose their sense of smell have triple the odds of dying within five years. Some speculate neurodegenerative disease is involved.
Together, Aβ and Neurodegeneration Spell Cognitive Decline in Three Years
Data suggest Aβ-dependent and –independent pathways combine forces to compromise cognition in otherwise healthy people.
Cerebrospinal Fluid Aβ Inches Closer to Bona Fide Diagnostic
When strict quality control standards are followed, low Aβ in cerebrospinal fluid accurately predicts amyloid plaques in people with cognitive impairment in clinical practice.
Drug and Biomarker Candidates for C9ORF72 ALS and FTD
Compounds that bind RNA temper toxicity related to ALS and FTD.
Neural Circuitry Goes Haywire in Both Sporadic and Familial AD
Connections across neural networks break down as cognition declines in people with different forms of AD, suggesting the wiring problems may be a hallmark of disease progression.
Searching for Evidence of Neurodegeneration in the Blood
Researchers continue to screen blood for factors that signal neurodegenerative disease.
Exosomes Stand Out as Potential Blood Biomarkers
Could exosomes—tiny parcels extruded from cells—make for a blood-based Alzheimer’s marker?
Alzheimer’s Disease: In the Eye of the Patient?
Researchers are looking to the eye for a cheap, easy way to detect Alzheimer’s pathology in the brain.
Crenezumab Disappoints in Phase 2, Researchers Remain Hopeful
At AAIC 2014, crenezumab Phase 2 trial results stirred debate.
Inflammation in Midlife May Presage Cognitive Decline
In a large retrospective study, people with the highest plasma levels of an inflammatory protein experienced the greatest decline in reasoning abilities over the next 10 years.
A Blood Test for Preclinical Prion Disease, But Will It Be Used?
An amplification-based test picks up minute amounts of prion protein in the blood of asymptomatic carriers, but researchers wonder whether regulators will want to screen the population.
Brain Training Database: Treasure Trove for Preclinical Alzheimer’s Research?
While scientists remain on the fence over whether computer games benefit cognition, some are finding new uses for gaming data in clinical trial research.
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