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At AAIC, new data on three anti-Aβ antibodies reinforced a sense of hope that Aβ immunotherapy may yet work out. Challenges with each antibody notwithstanding, all four leading candidates, including crenezumab, are now in Phase 3.
Probing this this Alzheimer’s risk factor, scientists find a novel variant, but no consensus yet on how this cell surface receptor increases risk for disease.
In some people, proteins in the cerebrospinal fluid trend toward an Alzheimer’s-like profile as early as age 45.
A behavioral variant of Alzheimer’s disease is not accompanied by shrinking of the frontal cortex. Rather, these patients have similar patterns of atrophy as those with typical AD.
In children as young as 9 who carry a presenilin 1 mutation, researchers detect subtle functional and structural brain changes.
Neuron-derived vesicles floating in the blood carry protein signatures that flag lysosomal dysfunction. Could they detect preclinical Alzheimer’s disease?
Levels of a neuronal protein in blood correlated with rate of decline in two U.K. cohorts.
In separate studies, researchers propose that high CSF ferritin and D-serine could become biomarkers to predict declining cognition in Alzheimer’s disease.
The signature fall of cerebrospinal fluid concentrations of Aβ that herald Alzheimer’s may be preceded by a brief boost.
Two large studies measured the occurrence of amyloid pathology in people with AD and other dementias. They confirm that amyloid may precede dementia onset by more than two decades, and rises with age, particularly in people with the ApoE4 gene.
Scientists find neurodegenerative proteins squirreled away in the skin cells of patients. Could this present an untapped source of biomarkers?
Several different striatal markers may help researchers track early deterioration in Huntington's and Parkinson’s diseases.
People with at least 16 years of education are less likely to accumulate markers of neurodegeneration in their brains, says a cross-sectional study.
Deep brain stimulation helps many people with Parkinson’s, but how it does so remains a mystery. A new study suggests it normalizes brain rhythms.
The highs and lows of cerebrospinal fluid Aβ and PET amyloid imaging don't necessarily agree.
