Large Grant for Chronic Traumatic Encephalopathy Biomarker Study
Researchers will follow former football players at risk for the disorder to identify the best biomarkers and clinical criteria.
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Countdown to Alzheimer’s: Can Fluid Biomarkers Predict Progression?
A small set of biomarkers in CSF and plasma may predict progression to Alzheimer’s within three years.
Biomarker Study in Down’s Syndrome Population May Yield Clues to AD
NIH announced a five-year study of Alzheimer’s biomarkers in middle-aged people with Down’s syndrome.
Scientists Eye Ocular Movements for Clues to Brain Pathology
Altered responses to visual stimuli could signify the extent of TDP-43 pathology in the brain, researchers predict.
Stressed Out: RNA-binding Protein Inhabits Granules in ALS, FTD
Meet RBM45. This RNA-binding protein and relatively new player in the ALS field associates with stress-induced structures in the cytoplasm and nucleus.
Neurofilament Light Chain: A Useful Marker for AD Progression?
The protein creeps up in the cerebrospinal fluid as the disease worsens.
Young ApoE4 Carriers Wander Off the ‘Grid’ — Early Predictor of Alzheimer’s?
Grid cells in the entorhinal cortex help with spatial navigation, and the cells’ function falters in young people at risk for AD.
Not Sexy but Oh-So-Important: Committee Blesses Way to Measure CSF Aβ
Moving toward a common standard for fluid-based Alzheimer’s diagnosis in routine clinical care, an intergovernmental metrology agency has certified a way of quantifying Aβ42.
Cerebrospinal Fluid Neurogranin Correlates with Markers of Neurodegeneration
Levels of CSF biomarker neurogranin correlate with imaging measures of synaptic integrity in ADNI cohort.
Paper Alert: Longitudinal Data Support CSF Neurogranin as an Early Synaptic Marker of Alzheimer’s Disease
Neurogranin could be a promising early CSF biomarker of Alzheimer’s disease.
When There's No Amyloid, It’s Not Alzheimer’s
Postmortem pathology confirms that some people who were diagnosed with AD during life had no appreciable amyloid in the brain, leaving researchers to puzzle over what caused their cognitive decline.
Suspected Non-Alzheimer Pathophysiology: It’s Not Exactly a Snap
Scientists struggle to understand neurodegeneration in the SNAP syndrome.
At AAIC, Researchers Debate Neurogranin's Measure as a Marker
The synaptic protein abounds in the cerebrospinal fluid of AD patients and in those in the prodromal phase of the disease.
Biomarkers Differentiate Parkinsonian Diseases and Forecast Decline
Can proteins in the cerebrospinal fluid help tell movement disorders apart and predict who will develop dementia?
CSF Aβ Assays Remain Fickle: Robots to the Rescue?
Variability still plagues CSF biomarker measurements, but automated systems offer hope of a diagnostic assay.
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