FDA Gives a Nod for Alzheimer's and Parkinson's Biomarkers
Qualification could follow, but only if trial sponsors fork over fresh data.
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More Alzheimer’s Journals Starting Up This Spring
Two new open-access journals will cover specialized areas of Alzheimer’s research.
Living on the Edge: Moderately Low Aβ42 in CSF Predicts Decline
Cognitively normal people with levels of CSF Aβ42 near the cutoff point associated with amyloid pathology are likely to cross that threshold within three years.
Tau PET Fits With CSF, Grows Over Time, Picks up Frontotemporal Cases
Early data suggest that the T807/AV1451 signal relates to cerebrospinal biomarkers of Alzheimer’s, intensifies by up to 10 percent a year, and might nail diagnoses beyond typical AD.
Structure of Microglial Receptor Offers Clues for PET Ligand Design
For the first time, scientists report a crystal structure of TSPO, a potential target for PET imaging of neuroinflammation.
Lumbar Puncture: Heading Off the Dreaded Headache
Spinal taps have a bad rap. Are headaches really all that common afterwards, and are there ways to prevent them?
In Aging Brain, Blood-Brain Barrier Starts Leaking in Hippocampus
Imaging technique borrowed from cancer care shows that leaks are worse in people who are cognitively impaired.
Approved Amyloid Imaging Agents Work About Equally Well
All three PET agents demonstrate roughly equivalent abilities to detect brain amyloid, a new analysis finds.
New Biomarkers? Synaptic Proteins in Spinal Fluid Predict Cognitive Decline
High levels foreshadow cognitive loss, hinting at utility as early diagnostic biomarkers.
API Biomarker Data Mirror DIAN’s, Support Progression Models
Cross-sectional biomarker data from the Colombian kindred confirm models of biomarker progression, but suggest an earlier drop in brain metabolism.
Protein Marker Distinguishes Prion Disease from Rapid Alzheimer’s
Measuring total prion protein in cerebrospinal fluid could help clinicians differentiate between prion disease and rapidly progressing forms of dementia.
Antibody Probe Seeks Aβ Oligomers in MRI
Scientists claim that MRI detects an Aβ oligomer-specific probe delivered to the mouse brain through the nose.
Large Studies Agree: Brain Amyloid Accelerates Cognitive Decline
Researchers at CTAD added to growing evidence that brain amyloid accumulation presages cognitive decline, although several different factors influence how fast that decline will happen in a given person.
New Target Has Legs: Tau PET, Mice, and Antibodies
Researchers at CTAD advanced tau research on several fronts, correlating tau PET with Braak stage and memory loss, and introducing a new tau model and therapeutic antibody.
CTAD Shows Alzheimer’s Field Trying to Reinvent Itself
A sense of change on all fronts pervaded the Clinical Trials on Alzheimer’s Disease conference. Scientists shared their early experiences of what works and what does not as they begin trials with newly defined cohorts, new diagnostic criteria, and new outcomes.
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