Does Clusterin Interact With Aβ to Kick Off Neurodegeneration?
A combination of high clusterin and low Aβ42 in cerebrospinal fluid associates with early Alzheimer’s neurodegeneration, hinting at a mechanistic interaction between the proteins.
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Lower Motor Neuron Pathology Links ALS and FTLD
Evidence builds that amyotrophic lateral sclerosis and frontotemporal lobar degeneration sit on the same pathological spectrum, but scientists are unsure how the disease marker TDP-43 fits in.
Biomarker Panel Predicts Slow or Fast ALS Course
A small panel of fluid biomarkers could predict a slow or fast disease course in amyotrophic lateral sclerosis.
Do Tau Tracers Track Cognitive Decline in Disease?
In the early days of tau brain imaging, neurofibrillary pathology appears to match up with the subtle cognitive decline of presymptomatic Alzheimer’s.
More Evidence for AD Starting Without Brain Amyloid
People with neurodegeneration but not brain amyloid surface in two new studies of preclinical AD, suggesting this odd population is both legitimate and potentially large.
Tau Biomarkers—More Informative Fragments in Spinal Fluid?
Tau fragments in cerebrospinal fluid might lead to better prognostic and diagnostic tests.
Speed of Biomarker Changes Herald Alzheimer’s Disease
Among cognitively healthy older adults, the rate of change in cerebrospinal fluid biomarkers helps predict who will develop Alzheimer’s disease.
Can Brain Metabolism Predict Huntington’s Symptoms?
People who carry the Huntington’s gene develop progressively abnormal brain metabolism a decade or more before diagnosis.
Parkinson’s Foundation Encourages Data Mining
Interested in Parkinson's? Apply for access to data and tissue samples, and funds to study them, from the Michael J. Fox Foundation.
Paper Alert: Preclinical Alzheimer’s Stages Predict Progression
Proposed preclinical stages for Alzheimer’s disease predict well who is most likely to progress to Alzheimer’s dementia.
Tau Tracer May Light Up All Tauopathies
The first report on PBB3, the latest tau ligand for brain imaging under development, suggests it binds all types of tau aggregate.
Non-Motor Symptoms Are an Early Sign of Parkinson's
A new study supports the idea that non-motor symptoms of Parkinson's disease may aid earlier diagnosis.
Going to Biomarker Extremes to Find Rare Alzheimer’s Variants
Researchers nabbed rare variants in Alzheimer’s genes by sequencing DNA from people with very high or very low levels of cerebrospinal fluid biomarkers.
Fluid Biomarkers Give Clues to Disease Progression in Parkinson’s
Preliminary data from Parkinson’s Progression Markers Initiative suggests that cerebrospinal fluid biomarkers distinguish the most rapidly progressing form of Parkinson’s.
Brain Connectivity Reveals Preclinical Alzheimer’s Disease
Brain connections weaken years before cognition in sporadic and familial Alzheimer’s.
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