HAI—Aβ: First in Alzheimer’s Cascade, or Just Another Player?
Scientists worldwide now perform amyloid imaging on scores of research participants to figure out how Aβ buildup relates to other markers of neurodegeneration...
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New Assays for Aβ Oligomers—Spinal Fluid a Miss, Brain Awash
Like a blue moon, could oligomeric amyloid-β in the cerebrospinal fluid (CSF) be too rare to be informative?...
HAI—Sharper Curves: Revamping a Biomarker Staging Model
Clifford Jack's hypothetical model showing biomarkers emerging at different stages of AD surged to the top of the Most-Popular-Slide-at-Conferences chart...
Zuers—Meeting Mixes Translational News and Debate
In a snowy mountain town in Austria, 75 scientists traded data and discussion of AD treatment approaches...
Insurance Coverage of AD Diagnostics? Not Without Better Data
The quest for health insurance coverage of brain amyloid scanning just took a twist...
Q&A With Merck’s Johan Luthman
Merck’s BACE inhibitor development program began enrolling last month for an 18-month Phase 2/3 trial of its lead compound (MK-8931) in mild to moderate AD...
Cortical Changes Precede Hippocampal in ApoE Carriers
With growing recognition that AD kicks off years before cognitive symptoms appear, scientists have ramped up efforts to understand early biomarker changes...
Merck Launches Largest Trial of BACE Inhibitor in AD
Merck announced this week that it has begun enrolling for the largest clinical trial of a β-secretase (BACE1) inhibitor in Alzheimer’s disease patients...
Chicago—ALS Database Opens for Business
Data miners: Start your search engines...
CTE Needs Consensus on Lifetime Diagnosis
When a new disease emerges, clinicians grapple early on with how to diagnose it...
CTE: Trauma Triggers Tauopathy Progression
What exactly goes on in the brains of people when blows to the head turn into a degenerative tau disease months or even years after the trauma...
Boxing: Study of Human Model for CTE Enters Second Round
Professional boxing offers a unique opportunity to study the natural history of CTE for an understanding of its presymptomatic pathogenesis and progression...
Multimodal Imaging: Structure, Function, Amyloid Not in Synch
As neuroimaging advances paint ever more detailed pictures of the brain’s wear and tear during Alzheimer’s disease, a glaring problem emerges...
Biomarker Progress? Picking the New, Better Measuring the Old
Individual labs are experimenting trying to improve the differential diagnoses of related dementias...
CTAD: EEG Gains Luster as More Trials Incorporate Biomarkers
The 5th Clinical Trials in Alzheimer’s Disease conference showcased the field’s pressing need for biomarkers as outcome measures...
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