API Echoes DIAN: Biomarker Changes Precede Symptoms by 20 Years
Evidence keeps building that the first signs of Alzheimer’s disease appear decades before symptoms...
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New Strategies for Early Diagnosis of AD
“Earlier” seems to be the new mantra in Alzheimer’s research...
Expanding the Network, DIAN Starts Showing Longitudinal Data
When the Dominantly Inherited Alzheimer Network gathered at the its hub at Washington University, St. Louis, Missouri, researchers exchanged new science on ARIA...
Can Epigenetics Explain Variable Progranulin Expression?
Researchers got something new to think about with respect to how the cell controls expression of the disease-linked gene progranulin...
Plasma Markers for Alzheimer’s—Slowly But Surely?
The hunt for blood-based Alzheimer’s biomarkers has struggled with a fundamental requirement of scientific research—that of reproducibility of the basic findings...
To Reveal or Not to Reveal? New Data on the Question
Researchers are trying to tackle whether and how to disclose genetic and biomarker data to people in both routine clinical care and research settings...
In Big Picture, Familial AD’s Biomarker Data Resemble LOAD
Researchers with eyes peeled toward prodromal AD probably see the diagram of the field’s five most validated markers in their sleep...
Can We All Agree on How to Draw a Hippo(campus)?
As to precisely where the hippocampus starts and stops on a magnetic resonance image, researchers have little consensus...
Cochrane Asks for Field’s Input on Draft Reporting Standards
Most researchers agree that clinical dementia papers need reporting standards, especially when it comes to diagnostic tests...
Metrology, Certification Heavies Take CSF Tests Under Their Wings
For cerebrospinal fluid tests of Alzheimer’s biomarkers, the time has come to grow up...
CSF Markers: Goodbye, Research Use Only; Hello, Clinical
When it comes to CSF Aβ and tau measurements, pharma companies developing Alzheimer’s disease treatments and diagnosing clinicians share similar goals...
New Assays for Aβ Oligomers in CSF Claim Femtogram Sensitivity
At the Alzheimer’s Association International Conference, two companies presented their progress toward oligomer-measuring assays...
Research Brief: Certain Serum Ceramides Increase Risk for AD
Results of a nine-year longitudinal study indicate that women with the highest amounts of certain types of ceramide in their blood are more likely to develop Alzheimer’s disease...
Paper Alert: DIAN Biomarker Data Show Changes Decades Before AD
Data from the DIAN paint a sobering picture, showing that a cascade of pathophysiological changes begins decades before a person is likely to develop familial AD...
Communication Breakdown: Multiple Networks Decline in AD Brains
A healthy brain switches between its different functional networks like a well-oiled machine, but as dementia takes over, communication becomes disorganized...
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