Reeling In Biomarker Data in Young Carriers, API Rocks Staging Boat
Scientists driving the Alzheimer's Prevention Initiative have been reporting at scientific conferences the first emerging biomarker findings from their human volunteers...
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Sirtuin Bests Huntingtin in Tug-of-War for Neural Survival
An excess of sirtuin one-ups mutant huntingtin in mice, saving neurons and delaying Huntington’s disease...
Research Brief: Evidence Supports Model of AD Biomarker Progression
A popular model of Alzheimer’s disease progression proposes an ordered sequence by which the main biomarkers change...
Research Brief: Hippocampal Hyperactivity Tied to Early MCI Atrophy
Alzheimer’s disease researchers have puzzled over a strange surge of hippocampal firing in some seniors at the cusp of mental decline...
EEG: Old Method to Lend New Help in AD Drug Development?
CTAD attendees got an earful about an arguably neglected topic in Alzheimer’s research, that is, the use of event-related potentials (ERP) as biomarkers of disease...
EEG: Coming in From the Margins of Alzheimer’s Research?
Regular visitors to Alzforum will be familiar with the use of PET, MRI, and cerebrospinal fluid measurements as markers for AD, But these are not the only AD biomarkers...
NEALS: Desperately Seeking ALS Biomarkers
Researchers studying amyotrophic lateral sclerosis (ALS) have plenty of drug ideas to try, but a great problem in figuring out if they work or not...
Family History Affects Biomarkers, Science Tracks Their Course
Findings strengthen the case for using biomarkers to determine who is at risk for AD before symptoms develop...
Amino Acid Clocks ALS Progression?
ALS has joined the growing list of neurodegenerative diseases characterized by fluctuations in the amino acid N-acetylaspartate (NAA)—but with a twist...
Tracking Huntington’s: Could Histone Protein Hit The Mark?
In the quest for a Huntington’s disease biomarker—one that reliably tracks disease progress and therapeutic response—researchers have so far come up short...
New Neuropathologic Guidelines for AD Almost Ready for Primetime
New U.S. guidelines for the neuropathologic assessment of Alzheimer’s disease (AD) and related conditions are getting close to being finalized...
EU Consortium Applies Nanotechnology to Study AD
Researchers are starting to see opportunities for nanomedicine, the application of nanoscale materials and processes to medical problems, in AD...
Are Soluble APP Fragments Markers for ALS?
Readers could be forgiven for doing a double-take at the title of a recent paper linking APP—best known for its role in Alzheimer’s disease—to ALS...
Paris: Standardization a Hurdle for Spinal Fluid, Imaging Markers
In the fall of 2009, a large quality control (QC) program started comparing measurements of cerebrospinal fluid (CSF) biomarkers from labs across the world...
"Autoantibody-omics" Yields Potential Blood Biomarkers for AD
Though Alzheimer’s is not typically considered an immune disease, serum autoantibodies just may hold promise as a blood-based AD diagnostic...
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