11617 RESULTS
COMMENT The Enron Collapse and Amyloid Formation What, you might ask, could the Enron collapse have to do with amyloid formation? The answer is, everything, in a sense. If one takes an otherwise stable corporation and begins executing business strategies that des
COMMENT Mattson's group has been pursing the role of telomerase in the brain, and the results look increasingly interesting suggesting that telomerase might be involved in stress or immune responses. 0 bwolozin
COMMENT This paper begins to build up our understanding of the machinery that might be involved in inclusion body formation. 0 bwolozin
COMMENT Posttranslational modification of the cytoplasmic tail of APP has emerged as an important mechanism for controlling APP metabolism and Aβ generation. These phenomena can be divided into two basic cellular phenotypes: modifications that regulate the α- and
COMMENT One of several studies that show that APH-1 and PEN-2 function together in the gamma-secretase complex. 0 edkoo
COMMENT Interesting study that optimizes an in vitro gamma-secretase cleavage assay. While the results have been reported elsewhere mostly from intact cells, this is a thorough study with important confirmations using a different system. 0 edkoo
COMMENT The paper from Kahn and coworkers is interesting and deserves greater attention. The expanded life expectancy due to leanness caused by a selective loss of insulin signalling in adipose tissue may point to an active metabolic role of that tissue. In this
COMMENT This clearly demonstrates the involvement of amyloid in potent dystrophic neurite or curly fibre formation as seen in AD. Although it remains to clarify the chemical structure of amyloid b-protein, i.e., fiber, oligomeric or beta-structure, a link between
COMMENT This work is a nice adjunct to the Bioessays review by Lu et al (Feb 2003). Animal models of altered pin1 levels/function are essential for assessing the role of pin1 in neurodegeneration, and its potenital as a therapeutic target. 0 ivincent Proline-dire
COMMENT The increasing number of isoform-specific pathological effects of ApoE4, which were so effectively reviewed by Gabrielle Strobel, suggest that ApoE4 may exert its pathological effects by several different mechanisms whose relative importance are context-d
COMMENT This study by Redwine and colleagues is very well done and meticulous. It convincingly demonstrates reduced volume of the dentate gyrus by 100 days of age in the PDAPP transgenic mouse model of Alzheimer’s disease. Aβ-containing plaques have been shown to
COMMENT The elegant data from both labs are quite consistent with the notion that APH-1 and PEN2 have important roles in stabilizing the PS complex and in promoting endoproteolysis. Indeed, we presented data in Orlando that fully supported these findings (our wor
COMMENT It has only been a few months that APH-1 and PEN-2 were discovered as major players in γ-secretase function in the Notch pathway in C. elegans. Together with recent papers from Haass and Yu, the two present papers demonstrate compelling biochemical eviden
COMMENT I would like to add an important piece to the ApoE4 story, namely ApoE4 domain interaction. Since protein function is directly linked to protein structure and biophysical properties, our studies have focused on determining how ApoE4 differs from ApoE3 and
COMMENT Abandon your diets! Kahn and colleagues have examined the impact of selective loss of insulin receptors in adipose tissue on longevity in FIRKO (fat-specific insulin receptor knockout) mice. Disruption of insulin signaling appears not to be associated wit
