11617 RESULTS
COMMENT This paper is interesting. Pertussis toxin mimics certain aspects of bacterial inflammation and enhances traffic of T cells into the CNS, thereby favoring EAE-type inflammatory responses. One could speculate that some of the trial subjects may have harbor
COMMENT The key point of the Furlan et al. paper is that they used pertussis toxin as a necessary adjuvant to produce the autoimmune encephalitis; that is not the protocol of others who carried out Aβ vaccination experiments in transgenic mice. The results are ne
COMMENT The authors show inflammation in the CNS following use of pertussis and immunization with Aβ. Their ability to induce an EAE-type response in C57/Bl6 mice when it wasn’t seen in AβPP-transgenic mice may relate not only to the use of pertussis, but to the
COMMENT comments on this paper reinforce the point that the study of how mutant APP/Aβ may relate to synaptic
COMMENT The exciting paper by Egan et al. is a far-reaching collection of experiments ranging from cell culture to human behavior that convincingly demonstrate the differing properties of proBDNF molecules carrying val66 or met66 polymorphic substitutions and the
COMMENT Several lines of evidence show that BDNF is implicated in hippocampal long-term potentiation, learning, and memory in nonhuman species, but until now the involvement of this factor in human memory and hippocampal function has not been examined directly. I
COMMENT Connecting the Dots. 0 lgnmatrix
COMMENT This sounds fascinating! I can't wait to learn more about CDSs, and perhaps experiment with them! 0 ivincent
COMMENT The abstract for this paper does not adequately describe the findings of this work or their implications. I recommend reading the full paper. Essentially, the work suggests that tau hyperphosphorylation is not the work of a single protein kinase or phosph
COMMENT The conversion of p35 to p25 has been implicated as the underlying cause of cdk5 hyperactivation in many neurodegenerative conditions. The mechanism governing formation of p25 needs to be elucidated, and the present paper provides one such clue in the pos
COMMENT The observation that AICD and Fe65 are nuclear proteins (Minopoli et al., 2001; Kimberly et al., 2001; Cao & Sudhof, 2001; Gao & Pimplikar, 2001) and the similar proteolytic processing of APP and Notch have suggested the hypothesis that APP and it
COMMENT In this paper, Scheinfeld and colleagues from the D’Adamio laboratory extended their work on the interaction between JIP-1 and APP. JIP is JNK-interacting protein-1, which several groups, including the D’Adamio lab, last year showed to bind to the cytopla
COMMENT When introduced as a clinical tool in the 1980s, MRI transformed the field of clinical neuroscience. Visualizing the brain with exquisite anatomical resolution was one thing, but to accomplish this feat noninvasively, so that human subjects could be image
COMMENT In the present studies, Daniel Weinberger and colleagues have reported that valine (val) substitution to methionine (met) in BDNF was associated with a failure to localize in secretory granules and synapses. The studies using transfected neurons appeared
COMMENT We were impressed by the research presented in Egan et al., which clinches a decisive role for BDNF in cognitive processes in humans. In animal models there has been an increasingly strong basis supporting an important role of BDNF in cognitive function,
