11617 RESULTS
COMMENT Another nice study from this group. These longitudinal data provide insight into the rates of brain atrophy in patients with familial AD. They reinforce the notion that a lot of damage occurs prior to clinically recognized disease. If true for typical lat
COMMENT A straightforward study further documenting the complexity of Abeta production and deposition. Abeta is not just Abeta1-40 and Abeta1-42. 0 tgolde
COMMENT This study is arguably the most comprehensive study of FAD-linked PS mutations with respect to effects on secreted and intracellular Abeta production. Although there are only a few aspects of the study that are truly novel, some of the more subtle aspects
COMMENT The is an interesting and somewhat unexpected finding. At 100 days of age PDAPP mice show a small but significant decrease in hippocampal volume (12.3%). This is before there is measurable biochemical or immunohistochemical Abeta deposition. The main ques
COMMENT The demonstration by Finley et al that loss of function of the blue cheese (bchs) gene in Drosophila leads to adult-stage neurodegeneration may be a very important finding, with implications for a range of neurodegenerative diseases, including Alzheimer&#
COMMENT The well-documented commonality between protein misfolding or aggregation and a wide range of neurological diseases has resulted in significant efforts directed toward gaining an understanding of molecular mechanisms responsible for this process. In 1994,
COMMENT This interesting abstract indicates that a prodrug for uridine protects against mitochondrial and inflammatory damage in cultured cells and experimental animals. The result is not surprising, since uridine is known to protect mitochondria against free-rad
COMMENT Focus on the Mitochondrion in Neurodegenerative Disease Mitochondrial structure and function decline with age, and especially in age-associated diseases including neurodegeneration. Mitochondrial damage appears to be a primary cause for the development of
COMMENT The results of the trial of Coenzyme Q10 in Parkinson's patients are very encouraging and provide a rationale for longer-term therapy. There is a solid basis for believing that CoQ10 may also benefit patients with Alzheimer's disease, particular
COMMENT Very good overview of current status of the problems of in vivo imaging and the prospects. 0 fred.vanleuven
COMMENT The immunological concept in the treatment of conformational diseases, such as Alzheimer’s, is based on antibody-antigen interactions involving conformational changes in both antibody and antigen. Appropriate mAbs interact at strategic sites where protein
COMMENT Egan et al. have performed an extraordinary study ranging from population to molecular levels. BDNF val66met polymorphism was shown first to affect episodic memory and hippocampal activation. Met-BDNF was revealed to fail in trafficking into secretory ves
COMMENT I’d like to note two additional things that might have relevance here. First, there is a severe neurological response when another protein is coadminstered with PT (myelin oligodendrocyte glycoprotein, or MOG25-35) that seems much greater than that observ
COMMENT The study by Egan and colleagues deserves much attention because it attempts to track the role of BDNF in hippocampal function from human (!) memory traces down to the underlying molecular mechanisms. The observed polymorphism in position 66 of the pro do
COMMENT The adverse reactions of vaccines can have various and complex origins related to both the antigen and/or the adjuvant. We have previously addressed concerns about the use of full-length Aβ in vaccines, but adjuvants can also add to the toxicity of the pr
