Takaomi Saido on Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia.

COMMENT Discovery of a new potential biomarker for AD. 0 saido

Takaomi Saido on Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis.

COMMENT The same may apply to AD pathological processes. 0 saido

Roland Pochet on Calbindin Study: Is Calcium the Molecular Handle on Dysfunction in AD?

COMMENT I would like to stress that already in 1993, Sutherland MK, Wong L, Somerville MJ, Yoong LK, Bergeron C, Parmentier M, McLachlan DR published in Brain Res Mol Brain Res. 1993 Apr;18(1-2):32-42 Reduction of calbindin-28k mRNA levels in Alzheimer as compare

Todd E. Golde on Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

COMMENT This could be the best model for studying AD like tauopathies, as these mice develop tangles without mutations. The finding that this only occurs when mouse tau is KO'ed is very interesting.... 0 tgolde

Paul Chabun on Cholinergic Systems and AD: Dark Clouds and Silver Linings

COMMENT An important paper. It would be good to have an exhaustive list of anticholinergics listed in order of their atropine equivalent effect. pchabun 0

Akihiko Nunomura on The identification and characterization of oxidized RNAs in Alzheimer's disease.

COMMENT This study by Shan et al. provides important new evidence for increased RNA oxidation and the biological consequence of the oxidized RNA in AD. Significantly increased levels of oxidized RNA nucleoside, 8-hydroxyguanosine (8OHG) were previously reported b

Chris Link on Human Tau Is No Help to Worms

COMMENT Kraemer and colleagues have established a new animal model for the study of tau pathology: transgenic C. elegans nematode worms expressing normal and mutant human tau. These researchers find that transgenic worms with neuronal expression of human tau have

Amy Stout on Expanded Huntingtin Heightens Calcium Signaling

COMMENT This manuscript describes studies done by Tang et al. to uncover potential mechanisms for the neuronal cell death that occurs in Huntington's disease. These researchers are the first to show that huntingtin (the protein that, when mutated, causes Hun

Vincent Marchesi on Calbindin Study: Is Calcium the Molecular Handle on Dysfunction in AD?

COMMENT Amyloid peptide-induced behavioral deficits in transgenic models of Alzheimer's disease are tightly linked to depletion of calcium-dependent proteins in granule cells of the dentate gyrus. This work builds on earlier observations that described the r

Vincent Marchesi on Expanded Huntingtin Heightens Calcium Signaling

COMMENT This series of well-designed experiments shows that mutant forms of huntingtin (Htt) with expanded polyglutamines can, under certain circumstances, sensitize Inositol (1,4,5) triphosphate receptors (Ins3PR) to activation by InsP3. These InsP3 receptors li

Fred Van Leuven on Human Tau Is No Help to Worms

COMMENT This is an excellent study on a novel C. elegans model for FTDP-17 tauopathies, with an eventual bearing on AD. The worms were humanized for tau and overexpress either wild-type or mutant tau in isoform ¡§4R1N,¡¨ i.e., containing the four microtubule bind

Wallace Dembski on Blueberries for All?

COMMENT GREAT! golgotha 0

Sheldon Tessel on Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors.

COMMENT See Pettit et al. in Journal of Neuroscience. 0 nana4141 beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.

Fred Van Leuven on LTP and Memory Effects May Be the First Casualties in AD

COMMENT The header rather than the data come as a surprise, given the fact that APP(V717I) transgenic mice display a robust defect in LTP as well as in cognition (water maze) as early as age three to four months. This is in essence the most "early" phen

Takaomi Saido on Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.

COMMENT The work predicts future development of "gamma-secretase" complex studies. 0 saido