11619 RESULTS
COMMENT Mironov et al. utilize immuno-EM to localize PrPc within neurons and their processes in brain. Especially interestingly, they describe a subpopulation of neurons with markedly elevated PrPc labeling. More speculative is their interpretation that, in these
COMMENT Akt-1: The Good Guy Takes a Knock but Stays the Course Opening scene: Akt protects its king (i.e., neuron) from dark forces. Protein kinase B (PKB or Akt) is a family of serine-threonine kinases with three isoforms. Following activation by either of the n
COMMENT The paper from Kakiuchi and coworkers is very interesting for people like us who have been working in the field of ER stress and neurodegenerative diseases. I am amazed that the polymorphism in a UPR (unfolded protein response) molecule may be implicated
COMMENT Copper: A Role in AD? Recent exciting findings suggest that copper in drinking water is able to exacerbate the amyloid pathology and an associated learning deficit in the cholesterol-fed rabbit model of Alzheimer's disease (Sparks et al., 2002; Spark
COMMENT ER disturbance may result from protein misfolding or from perturbation in the ER calcium homeostasis. Both events can lead to the activation of one or more of the ER stress sensors, ATF6, PERK and IRE1. This cascade of events activates gadd 153 and eventu
COMMENT Recent observerations that thiazolidinediones (TZDs) may exert cardiotoxic effects may reflect events not mediated by the PPARγ receptor. We showed that TZDs have direct effects on astrocyte metabolism Dello Russo et al., 2003). The basis for this effect
COMMENT I think that copper is a neurotoxic substance that displaces the zinc in the cell-specific carbonic anhydrase enzymes in the brain, leading to their death and to the production of amyloid plaques. Cell-specific carbonic anhydrase enzymes in the brain prod
COMMENT Meffert et al. have provided a fascinating report, but the data are not compelling. The most intriguing finding, that RelA-GFP diffuses in dendrites in a distal-->proximal direction, is represented by photomicrographs (and quantifications thereof) that
COMMENT The paper from Kakiuchi and coworkers is interesting and deserves greater attention. Recent evidence indicates that ER stresses and unfolded protein response (UPR) are associated with genetic or neuronal degenerative diseases such as Alzheimer’s disease a
COMMENT The work by Rees et al. provides evidence that the proaggregating effect exerted by AChE towards β-amyloid is active also in vivo. This conclusion supports and puts in a more interesting perspective the search for AChE inhibitors acting as bifunctional ag
COMMENT I have to agree completely with the comments of Exley. The illustrations purporting to demonstrate
COMMENT Coping with Copper—Minute Amount of Metal Plaques in Rabbit Brain The article by Sparks and Schreurs provides evidence that copper is the water contaminant responsible for increased neuronal and extracellular accumulation of amyloid previously reported by
COMMENT commenting on this work in Science and elsewhere are premature in attributing this potentiation directly to
COMMENT Response to comment by Vincent Marchesi Dr. Marchesi provides a thoughtful summary of our study
COMMENT Studies of lymphocytes in AD make a frequent appearance in the literature. Papers have been published that describe effects of AD on lymphocytic apoptosis, telomere length, calcium (e.g., Sulger et al., 1999; Palotas et al., 2002), CD45, oxidative damage
