11619 RESULTS
COMMENT Increasing evidence from biochemical, epidemiological, and genetic studies links cholesterol levels to Aβ production and the onset of AD pathology. Total cellular cholesterol can regulate Aβ generation, as evidenced by decreased Aβ levels in cells treated
COMMENT This is an extremely exciting paper, which reports outstanding work from the group of investigators in Pittsburgh and their collaborators around the world. There is considerable evidence that the protein called amyloid may play an important role in the de
COMMENT In this study, YM Lu and colleagues have unambiguously demonstrated the significance of S1232 phosphorylation of the NMDA receptor subunit NR2A by the p25/Cdk5 kinase in ischemic-induced CA1 neuronal death. They elegantly show that inhibition of p25/Cdk5
COMMENT Reply to comment by Steve Barger: Activation of NF-κB by basal synaptic activity (as well as
COMMENT I think this issue is worth exploring, but I am concerned that the ability of a GPI-BACE chimera to cleave APP may be too artificial a model to tell us much about how the authentic BACE behaves. GPI-linked peptides would be expected to partition in rafts
COMMENT Despite the problems with chemical tractability, β-secretase (BACE) remains one of the most promising targets for the treatment of Alzheimer's disease. It has been known for some time that APP, BACE, and γ-secretase (presenilins and associated protei
COMMENT I think this is an excellent and exciting paper. Hopefully, direct imaging of AD pathology is just around the corner for patients. The compounds developed by Dr. Klunk and used by Dr. Hyman work extremely well for in-vivo two-photon work, and show promise
COMMENT This is a nice paper which represents a significant step forward, in my opinion. Stem cells have been touted as a theoretical panacea for a variety of neurological disorders, but their practical use has been limited by issues including a ready source, met
COMMENT I regard this work as very interesting and important for showing how somatic cell nuclear transfer can be used properly for therapies, and how it can augment the potential of stem cells, particularly ES cells. The work is very well done. 0 esnyder
COMMENT This paper is an extraordinary achievement. Studer et al. have built on the work of Sasai and colleagues in Japan who showed that embryonic stem cells (ES cells) can differentiate into dopamine neurons when grown on a special cell feeder layer (Sasai, 200
COMMENT Embryonic Stem Cells for Parkinson’s Disease This study gives further evidence that embryonic stem cells may provide a feasible source of dopamine neurons that could be used for cell replacement therapy for Parkinson’s disease (PD). Parkinson’s disease cu
COMMENT Seems interesting. 0 rpochet
COMMENT It seems Donepezil is relatively safe and can help people with additional problems other than just Alzheimer's disease. stevenbrenner 0
COMMENT DiDonato and coworkers have studied the cysteine-independent aggregation of two FALS-associated SOD mutants, H43R and A4V. They found that both mutants have reduced stability (as found by guanidine-HCl denaturation) and activity with respect to the wild-t
COMMENT Laurine et al. study lithostathine, a protein that has been shown to be overexpressed in the preclinical stages of Alzheimer's disease. Upon autocatalytic cleavage, lithostathine forms fibrils that have been found in the lesions of Alzheimer's d
