11619 RESULTS
COMMENT The solution of the crystal structure of DJ-1 is indeed a great step forward, and the localisation of the L166P mutation is very helpful. Vincenzo Bonifati and colleagues suggested that this might be in a helical region in their Science paper, and it is r
COMMENT This is an excellent paper; the data about the specificity of the antibody are quite convincing. The rationale behind the development of this antibody is clever, and the same general approach of misfolding-dependent "side-chain accessibility" ma
COMMENT These papers are important steps forward to clarify the exact function of DJ-1, and, in turn, to promote understanding of the pathogenesis of DJ-1-related and of classical Parkinson's disease. These studies report the crystal structure of human DJ-1,
COMMENT From the standpoint of someone who is interested in oxidative stress signaling, the crystal structure raises several interesting possibilities. First, the conversion of cys-53 to a cys-sulfinic acid is reminiscent of the change that occurs in the prokaryo
COMMENT This work further confirms the importance of axonal retrograde transport in the development of neurodegeneration (at least in motor neuron degeneration). Although whether the concept applies to Alzheimer research remains to be examined, it seems worth try
COMMENT We were the first to show that lithium fully prevents the activation of GSK-3 alpha in vivo. Indeed, we demonstrated that 7 mM lithium in drinking water prevented Abeta-induced translocation of GSK-3 alpha and beta into the nucleus in rabbit brain. This e
COMMENT I'd like to follow up on Sam Gandy's comment regarding the antagonistic effect of
COMMENT The concept of mutated SOD1 aggregate formation was previously evoked, but this article gives experimental evidence supporting this hypothesis. It remains now to explain why not all motoneurons (i.e. oculomotor nucleus) are not impaired. rpochet 0
COMMENT The study by Aisen et al. shows no benefit to rofecoxib or naproxen in patients with mild to moderate AD. Nevertheless, this negative study is an important contribution to the collective effort to evaluate therapeutic strategies to treat or prevent AD. Th
COMMENT The study by Paramithiotis and colleagues is meticulously performed and demonstrates that animals immunized with the Tyr-Tyr-Arg repeat motif of the prion protein (PrP) generate antibodies that selectively recognize the scrapie form of PrP. Surprisingly,
COMMENT This is the fifth published trial of antiinflammatory treatments for disease modification or symptomatic improvement in Alzheimer's dementia. Two early small studies showed an encouraging suggestion of disease modification (slowing or progression) in
COMMENT NSAIDS, ALZHEIMER'S DISEASE AND PUBLIC CITIZEN With regard to this news item please see my Open letter to Public Citizen's Health Research Group on Alzheimer's disease research. Science SAGE KE (21 Feb., 2003) [Full Text] ; BMJ (27 Feb., 20
COMMENT Phiel et al. (2003) show that Lithium (Li), an inhibitor of GSK3β and GSK3α, can decrease Aβ via inhibition of γ-secretase and of GSK3α. These new findings indicate that inhibition of GSK3α is an important therapeutic target in Alzheimer’s disease (AD). T
COMMENT HASTA LA VISTA, AMYLOID CASCADE HYPOTHESIS, OR WILL ACADEMIC DISHONESTY YIELD ALZHEIMER'S CURE? Please see my letter to Neuron editor regarding the article by Hock et al. Science SAGE KE (26 May 2003) [Full Text] [No-registration access link]. 0 pos
COMMENT A great paper, that explains well the physiopathological substrate of MCI. 0 andre.delacourte
