11625 RESULTS
COMMENT This is a very interesting paper that adds to our understanding of the in-vivo biology of plaques, and it would be interesting to add further nuances to these insights by comparing the effects of diffuse versus neuritic plaques on the integrity of dendrit
COMMENT The study of Lewy body disorders will be greatly advanced with the development and characterization of transgenic mouse models. Although most lines overexpress alpha-synuclein, not all lines have necessarily recapitulated LB-like pathology. It is also unf
COMMENT We thank Drs. Canet-Aviles and Cookson for their thoughtful comments regarding our recently
COMMENT I think that this is an interesting paper, and new for the future. The study in this paper was not blinded, had no group with placebo, and the groups were too small. I think that the authors of the paper should continue their study using intravenous immun
COMMENT The authors report that soluble oligomers of Aβ and other protein misfolding disease related peptides such as islet amyloid polypeptide (IAPP, diabetes), PrP106-126 (prion diseases), polyglutamine (PG, Huntington’s and other triplet repeat diseases) and α
COMMENT shows a direct molecular link between recessive parkinsonism and PD. As others have commented (Hardy and
COMMENT An interesting review. 0 nikos.robakis
COMMENT An extensive review of the field. 0 nikos.robakis
COMMENT This pilot study by Dodel et al. demonstrates the effect of passive immunization in Alzheimer’s patients with the intravenous immunoglobulin prepared from the plasma pools of normal, healthy donors, based on the fact that healthy individuals have circulat
COMMENT This study is in good agreement with earlier work by Moechars et al., 1999, which demonstrates alterations in both cognitive function and synaptic plasticity in mice transgenic for human APP695 (V642I) several months before amyloid deposition is detectabl
COMMENT Is the difference in the reported results explained by the fact that Borlongan and colleagues used mannitol to permealize the BBB? The fact that mannitol is a hydroxyl radical scavenger has me wondering whether the mannitol itself may be therapeutic? The
COMMENT A key paper accelerating the subsequent discovery of the members in the gamma-secretase complex. 0 yliao
COMMENT A critical initial study for validating immunotherapy of AD. 0 yliao
COMMENT The excellent study by Spiegelman and colleagues shows that the absence of PGC-1 α, a coactivator of transcription factors including the PPAR family of nuclear receptors, leads to Huntington disease-like neurodegeneration in the mouse brain. As mentioned
COMMENT Allosteric modulation of γ-secretase activity offers a new avenue for specific inhibition of Aβ42 production Using fluorescence lifetime imaging (FLIM), the authors demonstrate that certain NSAIDs known to specifically reduce Aβ42 levels without altering
