11625 RESULTS
COMMENT It would be interesting to consider this paper in relation to the work of Cataldo and Nixon indicating that endosomal and lysosomal enzymes and morphology are affected early in the course of AD. 0 Paul_Coleman
COMMENT The story of misfolded proteins and disease gets more complicated. 0 Paul_Coleman
COMMENT transmission is one event that affects learning and memory. Paul indicated in the comments that "synapses
COMMENT This paper is not really in favor of the cascade hypothesis: The neuroprotective role of sAPP could be lost in AD, in parallel to the amyloid marker. Loss of function of APP is not a part of the amyloid cascade (gain of toxic function). Second, in the cas
COMMENT Does this study support a dissociation between LTP and spatial memory? Itokazu and colleagues (1) report that DHA inhibits the induction of long-term potentiation in the CA1 area in rats, as is shown to be the case for Aβ in many studies. I'd also be
COMMENT To my knowledge, this is the first paper demonstrating the relationship between presenilin and inflammation, which might be associated with the paticular agressive nature of FAD caused by PS1 mutations. It seems, however, necessary and important to make a
COMMENT This is a beautifully done study and is timely. It will and should shift the focus in the field of Cdk5 biology to regulation of Cdk5 activity beyond p35 and p25. It also emphasizes the importance of cross-talk between Cdk5 and other protein kinases in ne
COMMENT Waking up demented: New ideas about anesthesia-induced cognitive impairment In an intriguing paper just published in Anesthesiology, Eckenhoff et al. seek an explanation for the commonly observed transitory, and sometimes persistent, cognitive impairment
COMMENT Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy Expression levels of α-synuclein are correlated with Parkinson’s disease in several ways. The most extreme example is the finding of a triplication of the normal wild-type gene in
COMMENT With regard to the recent focus upon a diet rich in fish and its protective effect against Alzheimer's disease, please allow me to point out that the assumption that this is attributable to omega-3 fatty acids may be misguided. There are two groups o
COMMENT since September 2003. Her current stage is now diagnosed as early middle AD. Any comments? gguts12 0
COMMENT The beautiful series of papers by Jucker and colleagues begin to paint a picture of how cerebrovascular amyloid deposition (or CAA) might occur: 1. Neuronally produced Aβ peptide appears to have the opportunity to deposit in the brain parenchyma as plaque
COMMENT Mechanisms leading to the formation of α-synuclein inclusions in Parkinson's disease (PD) and related α-synucleinopathies characterized predominantly by abundant fibrillary intracellular α-synuclein inclusions in neurons and their processes as well a
COMMENT This paper presents, for the first time, a quantitative method for predicting the rate of aggregation into filaments or other larger structures based on intrinsic (amino acid sequence, charge, hydrophobicity) and extrinsic (pH, ionic content, concentratio
COMMENT Interesting trial and...a nice try at the same time. Using too low a dose will generate no clear answers on gingko efficacy. In my opinion, the arm of 120 mg of gingko versus 240 mg of gingko versus placebo would be rational advice. So far, both doses hav
