John Breitner on Merck Withdraws Vioxx®

COMMENT is of probable interest to readers, and the Alzforum editors have asked me to comment. First, any

Milan Fiala on Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease.

COMMENT The authors should cite the literature on CSF levels of amyloid-β (total and 1-42). Without having a comparison and seeing a discussion of previous CSF studies, I do not know whether the reduced level in CSF is good, bad, or a chance event. Antibodies to

Nikolaos K. Robakis on Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila.

COMMENT A nice paper suggesting new APP functions. 0 nikos.robakis

Paul Aisen on Merck Withdraws Vioxx®

COMMENT What impact does Merck's withdrawal of rofecoxib have on AD patients? Some AD patients have been taking rofecoxib and other NSAIDs to treat the AD. There is little justification for this. Each large trial of rofecoxib for the treatment of AD or MCI h

Todd E. Golde on FRETting Pays off—NSAIDs Target Presenilins, Reduce Aβ42

COMMENT The findings are significant for three main reasons: First: They provide strong evidence that NSAIDs bind to and modulate γ-secretase function in the brain. This extends findings from Dr. Koo's and my laboratories (Weggen et al., Eriksen et al. refer

Andre Delacourte on Lipid raft proteome reveals ATP synthase complex in the cell surface.

COMMENT Alpha chain of ATP synthase is indeed a protein with many facets. One of them is that it binds to "early" tangles and could be therefore an interesting marker of the degenerating process in Alzheimer's disease. 0 andre.delacourte Associatio

Jie Shen on Recycling endosomes supply AMPA receptors for LTP.

COMMENT This new study from the Ehlers and Kauer groups provides important new insight into the molecular mechanisms underlying the expression of long-term potentiation (LTP), the principal cellular model for learning and memory. Prior work has established that i

Paul Coleman on Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro.

COMMENT These data are closely related to studies conducted by E. and E-M Mandelkow. Comments from them

luee rene on Amyloid Formation—Taking Things One Monomer at a Time

COMMENT It's interesting. lvjianbao 0

Kyle Wilcox on Focus on Aβ Fibrils: Targeting β-sheets and Foiling Them

COMMENT By a high-throughput screen using >3,000 small molecules, the authors found that 4,5-dianilinophthalimide (DAPH) inhibits the aggregation and neuronal toxicity associated with the Aβ1-42 peptide from the amyloid precursor protein, APP. After showing th

Takaomi Saido on Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro.

COMMENT Very suggestive in addressing the question whether tau phosphorylation is a cause or consequence of tauopathy. 0 saido

Takaomi Saido on Differences in the immune response to long term Abeta vaccination in C57BL/6 and B6D2F1 mice.

COMMENT Important and interesting. 0 saido

Andre Delacourte on A novel presenilin 1 mutation (Y154N) in a patient with early onset Alzheimer's disease with spastic paraparesis.

COMMENT This paper shows, one more time, that the very first clinical symptoms of FAD with early onset are not necessarily linked to memory. 0 andre.delacourte

Paul Coleman on Altered response to mirtazapine on gene expression profile of lymphocytes from Alzheimer's patients.

COMMENT This interesting paper reports an effect of a novel antidepressant on gene expression profiles of cultured lymphocytes derived from eight AD and eight control patients. To do this they used "homemade" cDNA arrays, representing 3,200 transcripts

Paul Coleman on Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice.

COMMENT The concept of AD increasing neurogenesis is extremely interesting, and the proposal that this may be a compensatory response plausible. These findings directly disprove an alternative hypothesis: that the memory deficits of AD are related to the clinical