11718 RESULTS
COMMENT This exciting new paper from the Seghal lab makes an unexpected connection between reactive oxygen species (ROS), lipid metabolism, and sleep. Previous work had shown that neurons release ROS-damaged peroxidated lipids when overexcited or stressed; these
COMMENT This is a fantastic study. It addresses fundamental issues of brain bioenergetic metabolism that relate and link to several AD-relevant phenomena, including neuron-glia interplay, apolipoprotein E biology, lipid metabolism, oxidative stress, circadian rhy
COMMENT One great drawback when studying proteins like TDP-43 is the incredible number of genes whose expression is controlled by this protein, and which become misregulated following TDP-43 aggregation in pathological conditions. From a therapeutic point of view
COMMENT Adapted from a LinkedIn post. In order to fully understand the biology of Alzheimer’s disease, to create new predictive models, and to identify novel causal and druggable targets, we need large-scale, unbiased omic analyses. For the last three years, my l
COMMENT Wang and colleagues' interesting study showed that a multidisciplinary diabetes management program in primary care settings was associated with a reduced risk of dementia incidence among patients with T2D in a cohort study in Hong Kong. Patients with
COMMENT A team of human anatomists, clinicians, and basic scientists have come together to systematically examine the controversy of intermediate leptomeningeal layer or SLYM in the brain. A preprint of the document is at this open-access link: https://osf.io/5mh
COMMENT A team of human anatomists, clinicians, and basic scientists have endeavored to examine the controversy over existence of SLYM, see open access document here https://osf.io/5mhtu/?view_only=e5a2bf6004dd498db87587ec8c32df9e drashutoshkumar_380926 0
COMMENT Might we consider that, if prions can induce Aβ seeding, microbes such as herpes simplex virus (HSV) and herpes varicella-zoster, which are transmissible, might as well? For example, studies have shown that HSV, other viruses, and many other types of orga
COMMENT Could sCJD be due to as-yet-unidentified transmission routes? Has transmission via eye procedures been excluded? 0 sumada_347611 Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients.
COMMENT In this study, we found that higher baseline levels of CSF microglial biomarkers were related to faster rates of CSF sTREM2 increase and CSF PGRN decrease. Elevated CSF p-Tau181 was associated with higher levels of CSF microglial biomarkers and faster rat
COMMENT Since the misfolded proteins have been found in eye tissues and tears—have medical procedures involving the eye been considered as possible transmission routes? sumada_347611 0
COMMENT Shen and colleagues applied the high-throughput SomaScan proteomic platform to measure more than 6,000 unique proteins in the CSF and plasma of participants with autosomal-dominant Alzheimer’s disease (ADAD) in the DIAN study, with the stated goal of info
COMMENT This study by Shen et al. focusses on DIAN CSF SomaLogic 7k analyses and makes use of the estimated years of onset (EYO) concept to better understand disease processes that are associated with AD pathogenesis and their involvement over time. It is particu
COMMENT This is a nice study that extends the exciting findings reported in Johnson et al., 2023, by using an alternative proteomics approach—Somascan in comparison to the previously used SRM-MS—to quantify many more protein changes in the CSF in the same cohort
COMMENT Apolipoprotein E (APOE) is a multifunctional protein crucial for maintaining lipid homeostasis and metabolism. Certain APOE polymorphisms increase susceptibility to a wide spectrum of diseases in humans, including coronary and peripheral vascular disease,
