Madhav Thambisetty on Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease.

COMMENT Jackson Roberts is the co-author of this comment. 0 thambisettym Unbiased proteomics and multivariable

Ashok Shetty on Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.

COMMENT In this study, the authors investigated how irisin could affect Aβ pathology in Alzheimer’s disease. They report that irisin treatment causes a reduction in Aβ pathology by stimulating increased neprilysin release from astrocytes. Additional analysis reve

Fernanda De Felice on Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.

COMMENT This is a beautiful study that adds insight into the neuroprotective mechanisms of irisin in Alzheimer’s experimental models. In my opinion, the main takeaway of this study is that irisin triggers the release of neprilysin by binding integrins on astrocyt

Borja del Pozo Cruz on Sedentary Behavior and Incident Dementia Among Older Adults.

COMMENT To me these findings are not surprising at all. Sitting all day long deteriorates pretty much all biological system in the body, including the brain. It is likely that most of these cases are related to vascular dementia, hence the observed effects with i

Henry Brodaty on Sedentary Behavior and Incident Dementia Among Older Adults.

COMMENT In this retrospective study, more sedentary behaviours were associated with an increased risk of dementia. The size of the study, the main length of follow up (6.72 years), and the careful statistical analyses covarying for usual demographic factors, exer

Jasmeer Chhatwal on Sedentary Behavior and Incident Dementia Among Older Adults.

COMMENT This paper can be used to better counsel patients on how lifestyle choices and dementia risk are related. In my opinion, the main strength of this study is a very large sample size, which enables the authors to control for many co-variates at once, e.g.,

Steve Nguyen on Sedentary Behavior and Incident Dementia Among Older Adults.

COMMENT The U.K. Biobank study findings are stronger than what the Women's Health Initiative Memory Study/Objective Physical Activity and Cardiovascular Health in Older Women, aka WHIMS/OPACH, study showed. In OPACH, higher total sitting time and longer mean

Colin Masters on Could Blood Transfusions Transmit Vascular Amyloid?

COMMENT This study of more than a million transfusion recipients sends us a warning signal of what might be in store. Several years ago we (Alnakhli et al., 2020) published a similar finding on 184 persons with death certificates from the 2,940-person cohort of A

Julia TCW on CSF Proteomic Panel Better Predicts Decline Than Do Classic AD Biomarkers

COMMENT This selective panel of 48 CSF protein study, found from deep discovery-based proteomics in AD patients defined by Aβ42, tTau, and pTau181 difference compared to control individuals, gives novel insights on biological, cellular process of current biomarke

James Doecke, Colin Masters on CSF Proteomic Panel Better Predicts Decline Than Do Classic AD Biomarkers

COMMENT Some of us are old enough to remember the 1986 useful proteomic discovery of a 14-3-3 spot on a two-dimensional gel, which proved to be of diagnostic value for Creutzfeldt-Jakob disease (Harrington et al., 1986). Since then, proteomic approaches on bioflu

Russell Swerdlow on CSF Proteomic Panel Better Predicts Decline Than Do Classic AD Biomarkers

COMMENT This paper continues a series of home runs by this group. By organizing measurements of diagnostically informative proteins into larger groups defined through functional or physical relationships, it give us blind men a more global appreciation of the pro

Gerold Schmitt-Ulms on CSF Proteomic Panel Better Predicts Decline Than Do Classic AD Biomarkers

COMMENT This paper follows close on the heels of several proteomic studies that interrogated biofluids for predictive AD biomarkers, including groundbreaking work from the Emory group and collaborators themselves. Whereas in their recent Johnson et al. Nat Neuros

Henrik Zetterberg on Could Blood Transfusions Transmit Vascular Amyloid?

COMMENT This is such an interesting article! It is known that neurodegeneration-related proteins, including Aβ, tau, α-synuclein, and TDP-43, have some prion-like characteristics in vitro and in some in vivo models, although they appear less infective and less ag

David Werring on Could Blood Transfusions Transmit Vascular Amyloid?

COMMENT These findings are intriguing, although there are some methodological limitations which mean that interpretation is challenging. First, the authors did not directly assess cerebral amyloid angiopathy (CAA) as an exposure, but instead used recurrent ICH as

Lary Walker on Could Blood Transfusions Transmit Vascular Amyloid?

COMMENT In this intriguing retrospective analysis of two large, independent databases, Zhao and colleagues report that the risk of spontaneous intracerebral hemorrhage (ICH) was significantly increased in recipients of red-blood-cell transfusions from donors who