11642 RESULTS
COMMENT This study highlights the urgent need for a better understanding of the mechanism for the development of ARIA. Postmortem analysis showed severe cerebral amyloid angiopathy accompanied by perivascular inflammatory infiltrates. The findings offer support f
COMMENT The data presented in this case report continue to support the hypothesis that the mechanism underlying ARIA closely relates to CAA and likely shares many mechanistic links with CAA-related inflammation (CAA-ri). These findings emphasize the importance of
COMMENT At Mayo Rochester we began use of lecanemab in eligible patients in late fall. It’s a positive step for our patients to have an additional treatment option to slow early Alzheimer’s disease, and it has been rewarding for our clinicians to be able to offer
COMMENT We are excited to see the work of Chou et al. suggesting a link between INPP5D and inflammasomes (Chou et al., 2023). Their findings dovetail nicely with our recent paper, which found the INPP5D in human brain has multiple transcription start sites and tw
COMMENT This is an interesting study to obtain additional insight into the higher prevalence of Alzheimer’s disease in women than men. Mice with transgenic CYP46A1 overexpression were used, and sex-specific behavioral changes were correlated with dendritic spine
COMMENT This is an interesting study by the Maioli lab, with possibly important implications for stratifying patients in AD trials with cholesterol-targeting interventions. Over the last year, our understanding of the links between cholesterol, AD risk genes, and
COMMENT (referencing Dr. Fox's comment). I have a hunch that hipp. vol. + MMSE + CDR-SB in a supervised model
COMMENT Perhaps the BrainSee algorithm is detecting thinning of cortical gray matter as in Satizabal et al., 2023. That said, a blood draw is easier for most patients than an MRI, and plasma p-tau217 immunoassay detects AD with 90-95 percent accuracy (Ashton et a
COMMENT In a side-by-side comparison between BrainSee and hippocampal volume to predict progression to AD-dementia in 409 aMCI patients, hippocampal volume performed with 65.0 percent sensitivity, 78.2 percent specificity and 71.6 percent balanced accuracy; Brain
COMMENT Until a century ago, most people used to die before the age of 50 with few exceptions, suggesting our creator did not expect us to live long enough to suffer from late-onset Alzheimer’s disease (LOAD). Kotredes and colleagues have tried to generate a mous
COMMENT According to Alzforum, there are 204 murine models of AD, showing the complexity of developing a model that mimics AD perfectly. The choice of the best mouse model depends on the specific questions researchers aim to address; there is no universally perfe
COMMENT Tau double phosphorylation at residues 202 and 205 is one of the hallmarks of brain tau aggregates and has been used over the last decades for neuropathological studies on tau aggregation using the AT8 antibody. In cerebrospinal fluid, multiple phosphoryl
COMMENT This new report by Franzmeier et al. is a beautiful continuation of investigations into the important interplay between Aβ, tau, and neuronal hyperexcitability in the context of Alzheimer's disease. There have long been reports of how the presence of
COMMENT In this paper, the authors conducted an interesting secondary analysis of CSF and longitudinal tau PET data from ADNI. CSF levels of GAP-43, a presynaptic protein important in neurodevelopment and in axonal regeneration, are increased in MCI and AD, and h
COMMENT The take-home message from this research article is that in AD, synaptic changes, manifested by increased levels of the presynaptic protein GAP-43, are closely associated with the accelerated spread of tau pathology. The study found that higher levels of
