11527 RESULTS
COMMENT It is fantastic to see confirmation of our study, published earlier this year, that human microglia and astrocytes engulf synapses in Alzheimer’s disease (Tzioras et al., 2023). Both of our studies found more synapses inside astrocytes than inside microgl
COMMENT The authors performed incredibly thorough analyses of synaptic structure in postmortem human brain which enabled, for the first time, a very detailed look into the interactions among synapses, astrocytes, and microglia as they relate to cognitive decline.
COMMENT This research by Maniv et al. provides further insights into the molecular connection between UBB+1 and the pathology of Alzheimer's disease (AD). UBB+1, a ubiquitin RNA frameshift mutation identified by van Leeuwen and colleagues more than two decad
COMMENT These findings are very intriguing. Given the importance of 3R and 4R ratios in neurodegeneration, the potential differential effects of acetylation on 3R and 4R could have important implications and warrant further exploration in cell-based studies and i
COMMENT I think it is quite intriguing that UBB+1 specifically targets AD pathologies (Aβ and p-tau), but not other pathologies, such as α-synuclein. It would be important to know how UBB+1 selectively modulates APP degradation, but not the degradation of other p
COMMENT Together with a recent study that solved the structure of GTP1 in complex with tau PHFs from an AD brain sample (Merz et al., 2023), now we have the CryoEM structure for the AD tau PHF:MK6240 complex, which is also obtained with a 1:1 stoichiometry. We ca
COMMENT Sun et al. provide a comprehensive assessment of human microglia phenotypes in the aged and Alzheimer’s disease brain. Utilizing the data-rich ROS/MAP cohort the authors established the presence of 12 different microglia transcriptional states, identifyin
COMMENT The paper by Xiong et al. represents a seminal contribution to our understanding of Alzheimer's disease from a functional genomics perspective, elucidating previously unrecognized aspects of the disease's molecular etiology. One of the most sign
COMMENT cite or comment on this earlier study, which seems highly relevant for the current finding. While
COMMENT Revision of Alzheimer’s Diagnostic Criteria: Double Negatives Won’t Do the Job The diagnostic criteria for Alzheimer’s disease (AD) have undergone a number of changes since 1984 (Knopman et al., 2019). Originally, they were based mainly on clinical assess
COMMENT It has been pretty tough to assign clear contributions of specific PTMs on tau in the disease process. Phosphorylation is relatively abundant on tau in pathological states, but is very heterogeneous. By contrast, acetylation is low abundance (but certainl
COMMENT I think this very interesting paper presents a plausible mechanism for selective 3R deposition; however, before we can really understand this, we would need to study the process in cells. Also, the spontaneous aggregation of full-length tau in solution is
COMMENT These intriguing results provide compelling insight into the differential effect of acetylation on assembly of 3R and 4R tau isoforms. The inhibitory effect of acetylation on aggregation of 4R tau is consistent with our previous studies (Cook et al., 2014
COMMENT This paper by Zhang and colleagues represents a remarkable piece of research that identifies a novel regulator of neurotoxic reactive astrocytes, which are implicated in various neurodegenerative disorders. Here, the authors have discovered that transmemb
COMMENT It is amazing to see three papers with complementary information indicating that CSF Dopa decarboxylase (DDC) is a novel biomarker that might be useful to identify disorders characterized by dopamine deficiency in their very early stages. More studies are
