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RESEARCH NEWS 2024-06-07 Research News A massive transmembrane complex, γ-secretase churns out the infamous peptides that can start a person on the path in Alzheimer’s disease. Aβ is produced when the secretase shaves three residues at a time from APP fragments within cell membra
RESEARCH NEWS 2024-05-31 Research News Sometimes being polite does more harm than good. When glia surround amyloid plaques, they keep their distance from one another in structured cellular nets. These manners are enforced by the axon guidance receptor Plexin-B1, according to a pa
RESEARCH NEWS 2024-05-31 Research News In recent years, several studies have suggested that the brain rinses itself of harmful waste, such as Aβ, during sleep. In the May 13 Nature Neuroscience, researchers led by Nicholas Franks and William Wisden at Imperial College London cast
RESEARCH NEWS 2024-05-30 Research News Aggregates of α-synuclein are the hallmark of synucleinopathies such as Parkinson’s disease and dementia with Lewy bodies, but could other protein inclusions contribute to pathology? Yes, say scientists led by Joseph Mazzulli at Northwestern
RESEARCH NEWS 2024-05-28 Research News Even before the first flicker of symptoms surface in a person who carries a pathogenic frontotemporal dementia mutation, signs of the disease can be found in their blood, in the form of neurofilament light (NfL). Shed from eroding axons, NfL
RESEARCH NEWS 2024-05-23 Research News The hunt for PET tracers that can detect four-repeat tau deposits has turned up two ligands, PI-2620 and APN-1607, that bind these fibrils, but neither has yet been validated for diagnostic use. In a May 7 preprint on bioRxiv, researchers le
RESEARCH NEWS 2024-05-23 Research News Over the past three decades, the incidence of dementia has been declining in the U.S. and Europe. One reason might be that people’s brains have been getting bigger, say scientists led by Charles DeCarli at the University of California, Davis
RESEARCH NEWS 2024-05-21 Research News After the ApoE3-R136S “Christchurch” variant had held off the inevitable onslaught of Alzheimer’s disease by three decades in a woman with a pathogenic familial mutation, her brain was riddled with amyloid plaques but mostly free of neurofib
RESEARCH NEWS 2024-05-17 Research News Little by little, amyloid immunotherapy is finding more use at U.S. clinics, with procedures in place to smooth patients’ experience. Two new developments may simplify things. First, Eisai and Biogen recently requested marketing approval for
RESEARCH NEWS 2024-05-17 Research News Over the last three decades, scientists have devised molecular shuttles that slip enzymes, antibodies, and other molecules into the central nervous system (CNS) by attaching them to the transferrin receptor, which ferries the cargo across th
RESEARCH NEWS 2024-05-16 Research News APOE4 strongly increases the risk of sporadic Alzheimer’s disease. Yet some carriers evade the disease entirely. Now, scientists led by Richard Mayeux, Caghan Kizil, and Badri Vardarajan of Columbia University in New York peg some of that pr
COMMUNITY NEWS 2024-05-10 Community News For decades, the U.S. Food and Drug Administration has taken a light touch to regulating diagnostic tests that use body fluids or tissues. Such assays, very much including cerebrospinal fluid and blood tests for Alzheimer’s disease, were ab
RESEARCH NEWS 2024-05-10 Research News For 30 years, APOE4 has ranked as the strongest genetic risk factor for Alzheimer’s disease, with two copies boosting the odds up to 15-fold. Now, scientists make the case that people with two APOE4 alleles are not merely at risk, but are de
RESEARCH NEWS 2024-05-09 Research News The Alzheimer’s risk gene phospholipase C-γ2 has been thought to act mainly in microglia. Now, in a May 1 preprint on bioRxiv, researchers led by Jean-Charles Lambert, Julie Dumont, and Julien Chapuis at Institut Pasteur de Lille, France, Mi
RESEARCH NEWS 2024-05-09 Research News Cross-sectional autopsy studies have suggested that, in Alzheimer’s disease, neurofibrillary tangles first appear in the locus coeruleus (LC) of the brainstem. Now, a longitudinal imaging study lends support to that theory. In the April 25 N
