6281 RESULTS
CONFERENCE COVERAGE 2024-08-16 Conference Coverage The γ-secretase enzyme complex—abandoned as a drug target after candidate molecules proved toxic—is getting another look. New research has correlated the degree to which presenilin mutations affect the enzyme’s propensity to churn out
CONFERENCE COVERAGE 2024-08-09 Conference Coverage Among the hundreds of studies presented at this year’s Alzheimer’s Association International Conference, held July 27 to August 1 in Philadelphia, one of the few that made a splash in the news was not news at all. Perhaps spurred by a
CONFERENCE COVERAGE 2024-08-09 Conference Coverage Often in medicine, case studies, their lack of statistical power notwithstanding, tell a more dramatic tale than summary data. In the first secondary prevention trial run by the Dominantly Inherited Alzheimer Network Trials Unit, overa
CONFERENCE COVERAGE 2024-08-09 Conference Coverage At early symptomatic stages of Alzheimer’s disease, amyloid immunotherapy taps the brakes on cognitive decline, but does not halt the disease. Many researchers think the full promise of plaque removal lies in prevention. If plaques wer
CONFERENCE COVERAGE 2024-08-09 Conference Coverage “I can feel the ground move under the podium.” No, not an earthquake. At this year’s Alzheimer Association International Conference, held July 27 to August 1 in Philadelphia, Stephen Salloway, Brown University, Providence, Rhode Island
RESEARCH NEWS 2024-07-30 Research News Why do memories falter with age? In a preprint posted on bioRxiv on May 22, scientists led by Omer Sharon and sleep researcher Matthew Walker at the University of California, Berkeley, suggested that tau pathology may be responsible. It curt
RESEARCH NEWS 2024-07-30 Research News Nearly a century ago, physicians realized that boxers who had sustained many hits to the head often became “punch drunk,” with symptoms such as slurred speech, poor balance, and tremors. The condition is now recognized as a form of parkinson
RESEARCH NEWS 2024-07-26 Research News Single-cell transcriptomics aficionados have raised the bar again. In a study published in Nature on July 24, scientists led by Li-Huei Tsai and Manolis Kellis at Massachusetts Institute of Technology, Cambridge, parsed the transcriptomes of
RESEARCH NEWS 2024-07-25 Research News Tau PET has become a valuable research tool, but questions remain about how well tracer uptake reflects underlying tangles, how plaques influence this relationship, and how effectively the scans could be used for diagnosis. In the July 24 Sc
RESEARCH NEWS 2024-07-23 Research News The latticework of extracellular protein that surrounds brain cells forms a particularly dense mesh around fast-spiking interneurons. Why do these cells need such thick coats? In the July 17 Nature Neuroscience, scientists led by Harald Sont
RESEARCH NEWS 2024-07-19 Research News Ever since loss-of-function variants in the gene for PILRA, short for paired immunoglobulin-like type 2 receptor alpha, turned up as protecting against Alzheimer’s disease, scientists have wondered why. Now, a cell biology “omics” study prof
RESEARCH NEWS 2024-07-19 Research News How do tau fibrils develop? In the July 19 Structure online, scientists led by Yoshiyuki Soeda and Akihiko Takashima at Gakushuin University, Tokyo, proposed that the protein first condenses into droplets, then folds into insoluble β sheets.
RESEARCH NEWS 2024-07-14 Research News Microglia respond to proteinopathies by changing their shapes and expression profiles in different ways. Here’s one that has been somewhat overlooked: rod-shaped microglia. These long, straight cells have been observed in several neurodegene
RESEARCH NEWS 2024-07-13 Research News Tau in the blood can identify people in the earliest stages of Alzheimer’s disease, but plasma markers for other tauopathies, not to mention TDP-43 proteinopathies, have been hard to come by. Now, suddenly it seems, the field may have both.
RESEARCH NEWS 2024-07-12 Research News The innate immune protein C1q seems to have a thing for neurons. Already implicated in synaptic pruning by microglia, now it is reported to also slow down protein production in neurons of the aging mouse brain. In the June 24 Cell, researche
