6283 RESULTS
RESEARCH NEWS 2024-04-11 Research News Rather than giving them more gas, can microglia be driven to clear amyloid plaques by letting up on their brakes? Yes, say scientists led by Marco Colonna at Washington University in St. Louis. In the April 3 Science Translational Medicine,
RESEARCH NEWS 2024-04-11 Research News Phosphotau-217 has emerged as one of the most promising diagnostic markers of Alzheimer’s disease. It might also be a good therapeutic target, say scientists led by Yingjun Zhao at Xiamen University in China. In the March 20 Neuron, they rep
CONFERENCE COVERAGE 2024-04-10 Conference Coverage For synucleinopathies, which include Parkinson’s disease, multiple system atrophy, and dementia with Lewy bodies, scientists currently have no way to slow the underlying disease progression. Many groups are on the hunt for ways to prev
CONFERENCE COVERAGE 2024-04-03 Conference Coverage The revelation that tau aggregates can pass between cells, corrupting their intracellular counterparts, changed how the Alzheimer’s field studies tau pathology. At this year’s AD/PD meeting, held in March 5-9 in Lisbon, Portugal, resea
RESEARCH NEWS 2024-04-02 Research News Could the key to detecting synucleinopathies be no more than skin-deep? In the March 20 JAMA, scientists led by Christopher Gibbons and Roy Freeman at Harvard Medical School in Boston detected phosphorylated synuclein in the skin of people c
CONFERENCE COVERAGE 2024-03-28 Conference Coverage With people now being treated with amyloid immunotherapy in the clinic, reducing the risk of ARIA has taken on a new sense of urgency. This inflammatory side effect occurs in people who have amyloid in small to medium-sized blood vesse
RESEARCH NEWS 2024-03-27 Research News While genome-wide association studies tie variants to disease risk, they don’t explain how those variants influence gene expression or pathology. In the March 21 Nature Genetics, scientists led by Vilas Menon and Philip De Jager at New York’
RESEARCH NEWS 2024-03-26 Research News The space between the arachnoid and pia meningeal layers encasing the brain is a landscape of connective tissue, blood vessels, and cerebrospinal fluid. Scientists debate how that fluid moves within the space and through brain tissue. Now, a
CONFERENCE COVERAGE 2024-03-23 Conference Coverage At this year’s AD/PD meeting, held March 5-9 in Lisbon, Portugal, no splashy Phase 3, or even Phase 2, data on tau-targeted therapies wowed attendees. Still, Phase 1 and preclinical data showcased a variety of therapeutic approaches th
CONFERENCE COVERAGE 2024-03-22 Conference Coverage Old drugs die hard. Despite a string of negative Phase 3 trials, HMTM, a derivative of the malaria drug methylene blue, resurfaced again at AD/PD 2024, held March 5-9 in Lisbon, Portugal. TauRx CEO Claude Wischik reported results from
RESEARCH NEWS 2024-03-21 Research News The macrophage and microglial receptor TREM1 whips up inflammation. In its tizzy, the receptor also perturbs myeloid cell metabolism and hastens cognitive decline in older wild-type mice and in two models of amyloidosis, according to scienti
RESEARCH NEWS 2024-03-20 Research News Brain lesions beset with smoldering inflammation, and myeloid cells around their edges, define multiple sclerosis. This might be due, in part, to the flipping of electron flow within microglia, propose Luca Peruzzotti-Jametti, Stefano Pluchi
CONFERENCE COVERAGE 2024-03-15 Conference Coverage A record 4,700 people from 70 countries attended the 18th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 5 to 9 in Lisbon, Portugal. Those who attended this hybrid meeting in person sometimes packed rooms
RESEARCH NEWS 2024-03-13 Research News Last year, scientists led by Tony Wyss-Coray, Stanford University, reported that Aβ induced formation of lipid droplets within human microglia, and attributed this to an uptick in a triglyceride synthesis enzyme. APOE4 aggravated lipid dropl
RESEARCH NEWS 2024-03-12 Research News Almost half of a person's DNA consists of retrotransposons, remnants of ancient viral infections that have jumped around the human genome. Retrotransposons are typically kept under wraps by epigenetics, but tau can unleash those restrai
