Forced Into Fat-Burning Mode, Microglia Gobble Up Plaques, Protect Neurons
Blocking glycolysis triggers microglia to crank up lipid metabolism, boosting ATP production and improving phagocytosis. In Alzheimer’s disease, the opposite happens.
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Blocking glycolysis triggers microglia to crank up lipid metabolism, boosting ATP production and improving phagocytosis. In Alzheimer’s disease, the opposite happens.
18F-Cholestify binds to the enzyme that generates 24-hydroxycholesterol, which readily clears the blood-brain barrier.
With lecanemab likely to garner FDA approval next year, Alzheimerologists are pondering how clinical practice, and their science, will be transformed.
Analysis of 168 metabolites in one blood sample foretold 10-year risk of developing common disorders.
VAMP2 helps distinguish pure dementia with Lewy bodies from DLB with Alzheimer’s. A synaptic protein panel distinguished FTLD-TDP-43 from FTLD-tau.
Slow clearance of an MRI tracer offers evidence of inefficient glymph transport in the brain.
Staying lucid as a centenarian may depend on the immune system you inherit.
Sharp at 100+? Thank You, Genes. Thank You, Immune System. In Hydrocephalus, Does Slow Drainage Cause Dementia? Differential Diagnosis: Can Synaptic Proteins Get It Done? Kuopio Alzheimer Symposium (9th) and Nordic Memory Clinic Conference (3rd)
The agency, under pressure from advocacy groups, considers uncertainty about efficacy to be acceptable.
The blood protein tempers APOE4 risk in E2 carriers yet accentuates it in E4 homozygote people.
The Parkinson’s-related proteins promoted pathological hyperphosphorylation of α-synuclein.
The animals had no plaques or tangles, although they are still young.
Drug sponsors Eisai and Biogen said they will apply for approval in Europe, the U.S., and Japan; more detailed data will be presented at CTAD.
Three drugs, targeting three different pathogenic mechanisms in Alzheimer's, dementia with Lewy bodies, and ALS, had trial data formally published this week.
Adults who hit this number were half as likely as their sedentary peers to develop dementia over seven years. Power walking for 30 minutes daily cut risk by 60 percent.
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