Tau Chimeras Do Make Fibrils—and a Chaperone Rips Them Apart
Inclusions in tau seed sensor cells are made of amyloid fibrils, say scientists at AD/PD 2023. In those cells, and in human neurons, a dis-aggregase shreds them.
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First Hit on Aggregated Tau: Antisense Oligonucleotide Lowers Tangles
Biogen/IONIS’s tau ASO BIIB080 dropped participants’ tau PET signal below baseline in six months of treatment, according to data from a Phase 1 study presented at AD/PD.
International Conference on Alzheimer's and Parkinson's Diseases 2023
Pumping Up Progranulin: Scientists Show New Efforts to Get it Done First Hit on Aggregated Tau: Antisense Oligonucleotide Lowers Tangles Tau Chimeras Do Make Fibrils—and a Chaperone Rips Them Apart Macrophages Blamed for Vascular Trouble in ApoE4 Carriers
Pumping Up Progranulin: Scientists Show New Efforts to Get It Done
Queen Sylvia of Sweden traveled to Gothenburg to welcome scientists to AD/PD. At the conference, the buzz was on about approaches to double levels of the lysosomal protein in FTD.
What About the Brain Shrinkage Seen with Aβ Removal?
Anti-amyloid therapy could compromise brain health, a meta-analysis claims. Others say the concern is overblown.
Neuronal Pentraxin 2 Binds Complement Protein, Protects Synapses
NPTX2 binds complement C1q, disrupting signals to microglia to destroy synapses.
Exercise May Not Keep People Sharp After All, Meta-Analysis Says
Authors say the evidence that physical activity improves cognition in healthy people is inconclusive. Others disagree.
Brain Endothelial Cells Are Diverse, Perturbed by Amyloid
Single-nucleus RNA-Seq of human brain finds regional differences in endothelial cell subtypes. Transcriptomes change in the presence of plaque or vascular amyloid.
Take a Deep Breath—It Just Might Lower Your Risk for Alzheimer’s
Volunteers who practiced daily slow-breathing exercises for a month lowered Aβ42 in their blood; could this diminish the risk of AD?
Masking a Splicing Site Compensates for TDP-43 Dysfunction
Antisense oligonucleotides prevent mis-splicing of stathmin-2 when TDP-43 abandons the nucleus in human induced motor neurons or in the mouse brain.
Exosomes From Living Mice Hint That Sexes Respond Differently to Amyloid
The protein content of extracellular vesicles sampled from hippocampal interstitial fluid depended on age, sex, and amyloid load.
Phospho-tau/tau Ratios: Better Markers than Absolute p-Tau Levels?
The p-tau217/tau217 ratio in the cerebrospinal fluid tightly correlated with amyloid, while p-tau205/tau205 best detected neurofibrillary tangles and neurodegeneration.
Neurodegeneration—It’s Not the Tangles, It’s the T Cells
Summoned by microglia, T cells trigger neurodegeneration in a mouse model of tauopathy. Does this happen in Alzheimer’s disease?
Legacy of A4 Secondary Prevention Study Goes Beyond Negative Result
The decade-long trial found no benefit for solanezumab in delaying progression, but laid the groundwork for subsequent prevention studies.
Could Calming Overactive Ryanodine Receptor Restore Autophagy?
These endoplasmic reticulum channels can flood the cytosol with calcium, disrupting lysosomal acidification and stalling autophagy.
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