What About the Brain Shrinkage Seen with Aβ Removal?
Anti-amyloid therapy could compromise brain health, a meta-analysis claims. Others say the concern is overblown.
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Neuronal Pentraxin 2 Binds Complement Protein, Protects Synapses
NPTX2 binds complement C1q, disrupting signals to microglia to destroy synapses.
Exercise May Not Keep People Sharp After All, Meta-Analysis Says
Authors say the evidence that physical activity improves cognition in healthy people is inconclusive. Others disagree.
Brain Endothelial Cells Are Diverse, Perturbed by Amyloid
Single-nucleus RNA-Seq of human brain finds regional differences in endothelial cell subtypes. Transcriptomes change in the presence of plaque or vascular amyloid.
Take a Deep Breath—It Just Might Lower Your Risk for Alzheimer’s
Volunteers who practiced daily slow-breathing exercises for a month lowered Aβ42 in their blood; could this diminish the risk of AD?
Masking a Splicing Site Compensates for TDP-43 Dysfunction
Antisense oligonucleotides prevent mis-splicing of stathmin-2 when TDP-43 abandons the nucleus in human induced motor neurons or in the mouse brain.
Exosomes From Living Mice Hint That Sexes Respond Differently to Amyloid
The protein content of extracellular vesicles sampled from hippocampal interstitial fluid depended on age, sex, and amyloid load.
Phospho-tau/tau Ratios: Better Markers than Absolute p-Tau Levels?
The p-tau217/tau217 ratio in the cerebrospinal fluid tightly correlated with amyloid, while p-tau205/tau205 best detected neurofibrillary tangles and neurodegeneration.
Neurodegeneration—It’s Not the Tangles, It’s the T Cells
Summoned by microglia, T cells trigger neurodegeneration in a mouse model of tauopathy. Does this happen in Alzheimer’s disease?
Legacy of A4 Secondary Prevention Study Goes Beyond Negative Result
The decade-long trial found no benefit for solanezumab in delaying progression, but laid the groundwork for subsequent prevention studies.
Could Calming Overactive Ryanodine Receptor Restore Autophagy?
These endoplasmic reticulum channels can flood the cytosol with calcium, disrupting lysosomal acidification and stalling autophagy.
Parabiosis Illuminates Modifiable Pathways of Brain Aging
Joining the circulatory systems of young mice with old evokes gene-expression changes in the brain that reflect in proteostasis, metabolism, and inflammation.
Does Flashing Light Really Lower Cortical Amyloid?
A new mouse study finds no consistent gamma entrainment, amyloid lowering, or microglial activation in response to 40 hertz light, raising questions about previous findings.
Decision Date on Leqembi Traditional Approval Set for July
The U.S. Food and Drug Administration will convene an advisory committee to guide its decision, which will affect how widely available the treatment will be.
In People with African Ancestry, ApoE3 Variant Ups Alzheimer's Risk
Carriers of R145C were more likely to get AD, but only if they co-inherited a copy of ApoE4.
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