Brain Within a Brain? Nested Organoids a New Way to Study Human Microglia
Transplanting a human cerebral organoid containing microglia into a mouse brain allows the cells to thrive in something close to their natural environment.
ALL NEWS
6572 RESULTS
Sort By:
- Most Recent
- Most Commented
Hi-Res Spatial Proteomics Uncovers Aspects of Alzheimer’s Disease Pathology
Multiplex analyses spy a new microglial subtype that surrounds Aβ plaques, and a type of neuron resilient to neurofibrillary tangles.
Paper Alert: Those Fibrils Floating in Brain Fluid Are Toxic
They can be neutralized by lecanemab, an anti-amyloid antibody designed to mop up Aβ protofibrils.
Reelin Variant Wards Off Dementia in Colombian Kindred Siblings
An amino acid change in this ApoE receptor-binding protein may have bestowed 20 years of resilience to a brother and sister carrying the presenilin Paisa mutation.
FDA Approves Rexulti for Agitation in Alzheimer’s
The D2 dopamine receptor agonist reduced agitation behaviors in Phase 3 trials of dementia due to AD.
Remembering Mary Jo LaDu
Scientists celebrated LaDu's scientific and academic career at Chicago memorial.
Tau Filaments Found Tethered Inside Alzheimer's Brain Exosomes
Bound up in vesicles extracted from Alzheimer's brain, tau filaments adopt their characteristic back-to-back C-shape. A mystery molecule is involved in tying them down.
Amyloid Atlas Showcases 261 Structures, and Counting
The public database includes information about the structure, polarity, and stability of both pathogenic and functional amyloid folds.
Are Hormones to Blame for High Tau in Women?
One study links early menopause to tangles in early AD, another finds a sex difference in the brain's stress response. Could hormones fuel women’s higher risk of dementia?
Whole Genome Analysis Nets New Lewy Body Dementia Gene
A deletion in the gene for a lysosomal ion channel popped out of a genomic analysis of LBD risk. So did rare structural variants in other FTD and ALS genes.
Long COVID and Dementia: The Link Is Still Elusive
While memory problems plague some people with lingering COVID symptoms, researchers do not yet understand what is going wrong in their brains.
In Tired Mice, TREM2 Addles Microglia
In sleep-deprived mice, TREM2 signaling activated microglia in a dysfunctional way, hobbling their endolysosomes and keeping them from digesting Aβ plaques.
And Then There Were Three: Donanemab Phase 3 Trial Positive
The antibody slowed decline by 35 percent, met secondary endpoints, will likely be approved. Major question: How to avoid severe ARIA.
New Arrows Aimed at Tau: Single-Domain Antibody, Peptibody, Vaccine
Scientists devised fresh approaches for curbing tau tangles that might better reach the protein inside cells, or target several pathologies at once.
Microglia Conflicted: To Help, or to Hinder, Tau’s March Across the Brain?
Data from TRIAD cohort cast activated microglia, egged on by ApoE4, as harbingers of tau pathology and neurodegeneration. Data from BioFinder hint that other microglia restrain these processes.
Current Filters
No filters selected