With Microglia, It Takes a Village to Connect the Dots
Scientists showed how pooling microglia from different donors, then putting them through cutting-edge analyses, can link genetic variation to functional change.
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From Phagocytosis to Exophagy: Microglia's Digestive Tract Dissected
At AD/PD, scientists zeroed in on endolysosomal mechanisms in microglia that may contribute to neurodegenerative disease. Blending omics with cellular studies leads them from genes and function.
Next Goals for Immunotherapy: Make It Safer, Less of a Hassle
Lilly’s Phase 3 antibody remternetug resembles donanemab, but without pesky antidrug antibodies; Prothena’s Phase 1 PRX012 may need fewer injections.
Synuclein Assay Passes the Sniff Test—What of Other Seeds?
Analysis of cerebrospinal fluid from the Parkinson’s Progression Markers Initiative identifies PD with high sensitivity and specificity.
TREM2 Protects the Brain From Herpes. The Virus Fights Back.
The microglial receptor activates an antiviral signaling cascade. The virus downregulates TREM2 expression after infecting microglia.
Risk Gene Conspiracy: Clusterin Binds CD33, Souring Microglial Taste for Aβ
Clusterin latches onto dimers of CD33 on the microglial cell surface, setting off inhibitory signaling that squelched phagocytosis.
All Roads Lead to TREM2: Gearing Up to Target This Receptor
At AD/PD, scientists placed more AD genes into microglial pathways, homed in on how TREM2 gets cleaved, debuted TREM2 agonists, and unearthed potential biomarkers.
Scientists Ask What Plaque Clearance Means for the Long Haul
At AD/PD, scientists showed 3- and 4-year amyloid immunotherapy data hinting at sustained cognitive benefits. The number of remaining participants is tiny.
What Happens After Amyloid Plaque Removal? Who Benefits Most?
Clearance triggers improvement in downstream markers of inflammation and neurodegeneration—but not in those who started with high tangle burden. (Clue: women.)
Attack From Within: How Ancient Viruses Resurface to Spread Tau
Envelope proteins from endogenous retroviruses help shuttle tau seeds between cells. Could HERVs fuel tauopathies?
Macrophages Blamed for Vascular Trouble in ApoE4 Carriers
Perivascular macrophages both produce and react to the apolipoprotein, releasing toxic reactive oxygen species that constrict blood vessels.
Tau Chimeras Do Make Fibrils—and a Chaperone Rips Them Apart
Inclusions in tau seed sensor cells are made of amyloid fibrils, say scientists at AD/PD 2023. In those cells, and in human neurons, a dis-aggregase shreds them.
First Hit on Aggregated Tau: Antisense Oligonucleotide Lowers Tangles
Biogen/IONIS’s tau ASO BIIB080 dropped participants’ tau PET signal below baseline in six months of treatment, according to data from a Phase 1 study presented at AD/PD.
International Conference on Alzheimer's and Parkinson's Diseases 2023
Pumping Up Progranulin: Scientists Show New Efforts to Get it Done First Hit on Aggregated Tau: Antisense Oligonucleotide Lowers Tangles Tau Chimeras Do Make Fibrils—and a Chaperone Rips Them Apart Macrophages Blamed for Vascular Trouble in ApoE4 Carriers
Pumping Up Progranulin: Scientists Show New Efforts to Get It Done
Queen Sylvia of Sweden traveled to Gothenburg to welcome scientists to AD/PD. At the conference, the buzz was on about approaches to double levels of the lysosomal protein in FTD.
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