Methods to Detect Amyloid Seeds Improve, Extend to Blood and Parkinson’s
Methods that trawl body fluids for amyloidogenic proteins are getting more sensitive and specific, and scientists are expanding the repertoire of oligomers they can detect.
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Tau PET in Down’s: Unique Patterns Among Alzheimer’s Types and Stages
At CTAD, tau PET data from people in different stages of various neurodegenerative diseases highlighted both commonalities and peculiarities.
Feeling Lonely: AD Pathology Gives People Sense of Disconnection
Cognitively normal people who harbor plaques in their brains are more likely to report feelings of isolation.
Exosomes and Antibodies Tie Plasma Aβ and Tau to Alzheimer’s
Researchers at SfN 2016 reported that oligomeric and exosomal forms in plasma predict AD as early as a decade prior to symptoms.
Paper Alert: Slotting TREM2 into Alzheimer’s Pathogenesis
Where does TREM2-dependent microglial activity fit into the staging diagram of Alzheimer’s disease?
In NFL Players, Brain Inflammation May Persist Years After Head Trauma
PET scans detect activated glial cells in current and recently retired professional football players up to 21 years after their last concussion.
More Evidence That Distinct Tau Strains May Cause Different Tauopathies
Strains injected into mouse brain seed tau aggregation at different rates and in different regions of the brain.
Imaging Myelin: Shining a Light on Early Alzheimer’s Pathology?
Using a new, quantitative MRI method, researchers find accelerated myelin deterioration in preclinical Alzheimer’s disease.
EMIF, GAAIN: Online Gateways to Reams of Alzheimer’s Data
Two international initiatives compile metadata from aging and AD studies into huge searchable catalogs in hopes of speeding research progress.
New Spectroscopy Method Detects Myelin Changes in Early ALS
Before any other changes, the fatty coating on peripheral nerve fibers breaks apart, heralding their degeneration.
With Amyloid Scan in Hand, Physicians Manage AD Differently
In Italian memory clinics, the PET scans resulted in diagnosis and medication changes for up to a third of patients.
The Making of a “Superager”: New Research Examines Neuroanatomy that Keeps Older Adults Sharp
Preserved brain networks may explain the exceptional memory prowess of some older adults.
Fluid NfL Shines, Tau PET Dims, in the Hunt for FTD Biomarkers
Researchers at an international frontotemporal dementia congress reported progress in finding markers that track disease, but no luck thus far with diagnostic markers.
Axon Damage May Hinder Recovery from Concussion, Spark Neurodegeneration
Neuronal markers in the cerebrospinal fluid suggest the degree of white-matter damage correlates with time needed for recovery, and that repetitive brain injury spurs amyloid deposition.
Homing in on Early Alzheimer’s Biomarkers: Does Connectivity Hold the Key?
Researchers at AAIC proposed several different measures of brain connectivity that may predict progression to AD.
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