Inside Out, or Outside In? ALS Turns on Monocytes in Blood
People with ALS—especially those who progress fast—express myriad inflammatory genes in their blood monocytes.
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Are CSF Assays Finally Ready for Prime Time?
In the field’s march toward automated testing, scientists for the first time used biomarker cutoffs determined in one cohort to predict amyloid accumulation in a second. It worked.
Next-Generation Tau PET Tracers Strut Their Stuff
Emerging data on new tau ligands raise hope of more signal, less noise, and help with a broad range of tauopathies. Read news culled from the AD/PD and HAI 2017 meetings.
Poly Dipeptide in Cerebrospinal Fluid Marks C9ORF72 Expansion Carriers
Unlikely a disease marker, poly glycine-proline might track therapeutic efficacy in clinical trials.
Blood Neurofilament Light a Promising Biomarker for Alzheimer’s?
The largest study yet on neurofilament light chain suggests plasma levels rise with disease and correlate with other signs of neurodegeneration.
Can Immune Gene Expression Predict Pace of Motor Neuron Destruction?
Unbiased screen turns up genes expressed in immune cells, both inside and outside the CNS.
Selecting Trial Participants Based on Tangle Pathology Might Improve Power
Trials enrolling people all at the same Braak stage would need fewer participants to show a drug effect, according to a new analysis.
Neurofilament Light Chain as Prognostic Biomarker in ALS
Study of disease subtypes boosts case for NfL as predictor of rapidly progressing ALS.
Multimodal Imaging Ties Tau to Neurodegeneration, and Symptoms
Combining PET with MRI reveals near-complete overlap of tau tracer uptake with cortical atrophy and clinical features in typical and atypical AD.
Consortium to Seek Biomarkers for Vascular Cognitive Impairment
NIH funds a five-year project to validate biomarkers for clinical trials.
Pee P75: A Potential Biomarker of ALS Progression?
ALS patients eliminate more p75 neurotrophin receptor than do healthy controls. P75 urine levels rise as disease worsens.
Touchdown for NfL: Blood Test Tells Parkinson's from Related Disorders
A simple blood draw may help distinguish garden-variety PD from other, less common parkinsonian disorders early in disease.
After Solanezumab: Where Should Alzheimer’s Research Go?
Branch out, scientists at Alzheimer’s Research UK conference say. Go after tau, glial activation, lipids, in a systematic way. Understand how these pathways connect to the amyloid hypothesis.
Solanezumab: Did Aβ ‘Reflux’ From Blood Confound Target Engagement in CSF?
Convened by ARUK to learn from the antibody’s billion-dollar bust, industry and academic leaders declare insufficient CNS target engagement, say peripheral sink did not work, and brainstorm how to move forward.
Amyloid Plaques’ Hold on Aβ42 Dampens Peptide’s Daily Rhythm
Diurnal variations disappear as less Aβ42 reaches cerebrospinal fluid. Findings may improve timing of daily amyloid treatments.
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