Can Biomarker Data Predict Individual Risk for Alzheimer’s?
Researchers debut a statistical model that uses MRI, CSF, and demographic data to compute a cognitively impaired person’s risk for progressing to dementia.
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Bloodborne Tau: Foggy Window into the Brain for TBI, Dementia
Tau in the plasma rises after traumatic brain injury, with cognitive decline, and progression to mild cognitive impairment.
Retinal Plaques May Enable Noninvasive Screening for AD
In a pilot study, a curcumin-based probe allowed researchers to detect retinal amyloid deposits in AD patients, but it remains to be seen if this can serve as an early biomarker.
Teasing Out the Brain Features Behind Cognitive Reserve
Researchers at AAIC presented several imaging measures that may help explain the phenomenon of preserved cognition in the face of AD pathology.
Longitudinal Data Say: Nope, CSF Markers Do Not Track Progression
AAIC presentations identified early imaging changes in aging and AD, and reinforced the idea that CSF markers change little over the short term.
Data from DIAN Revise Familiar Biomarker Trajectories
Rather than changing one by one, many biomarkers—including cognition, tau PET, hippocampal atrophy, and CSF p-tau—shift together, around the time of symptom onset in young adults with familial AD.
All Signs Point to Tau Tangles as the Culprit in Fading Memory
Researchers at AAIC reinforced the idea that tau pathology drives cognitive decline, although amyloid plaques were implicated in semantic memory deficits.
CSF and Brain Markers Highlight Different Facets of Dementia
Researchers at AAIC described different correlates of CSF and PET measures of Aβ and tau.
As Youth Fades, So Does the Fire of Glycolysis in the Brain
The aging brain winds down rapid glucose metabolism in regions that will go on to accumulate amyloid, perhaps raising the risk of neurodegeneration.
In Clinical Use, Amyloid Scans Change Two-Thirds of Treatment Plans
Interim data from IDEAS study find that amyloid PET has a greater effect in real-world practice than in research settings. Nearly half of people diagnosed with AD did not have the disease.
Finally, a Blood Test for Alzheimer’s?
At AAIC, researchers debuted a method that detects changes in plasma Aβ42 in people with brain amyloid. If confirmed, a widely available screening test for presymptomatic AD could follow.
Ring Around the Vessel: Enlarged Spaces Signal Vascular Disease
Gaps surrounding blood vessels in the brain may predict cognitive decline and vascular dementia.
Alzheimer’s Proteomics Treasure Trove?
Analysis of brain tissue from Alzheimer’s patients offers a glimpse of proteomic changes in the disease.
DLB Guidelines Get a Makeover
New diagnostic guidelines on dementia with Lewy bodies fold in science about sleep and the heart, two aspects that distinguish this disorder from Alzheimer’s and Parkinson’s.
At Risk, or Already Alzheimer’s? Elevated Aβ Predicts Cognitive Decline
Longitudinal ADNI data revealed that people with elevated Aβ declined toward AD, while those with normal levels maintained their cognitive abilities.
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