Does Serotonin Pathology Foreshadow Parkinson’s Disease?
In carriers of a PD-causing mutation, PET scans showed serotonin transporter loss before motor symptoms set in.
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Drawing Closer: Alzheimer’s Blood Test for Primary Care
Fully automated immunoassay could offer cost-effective screening for AD.
NfL: Useful in Differential Diagnosis?
A meta-analysis of 47 studies suggests CSF NfL is particularly elevated in a select few, suggesting it could help in differential diagnosis.
Do Brain Waves During Sleep Reflect Aβ and Tau Pathologies?
In healthy, older adults specific EEG patterns correlated with plaque and tangle burdens.
TADPOLE Challenge: Winners Forecast AD Symptoms
Using different techniques, contestants vied for the best way to tell which ADNI participants would develop clinical, cognitive, or imaging signs of Alzheimer’s disease.
Serial PET Nails It: Preclinical AD Means Amyloid, Tau, then Cognitive Decline
Serial amyloid and tau scans in cognitively healthy people indicate that the speed at which a person’s tau accumulates best predicts his or her future cognitive decline.
Amyloid-PET Results Lead Some to Ponder Assisted Death in Future
In a research study, one-fifth of healthy people who learned they were at high risk for AD said they might consider physician-assisted death as a future option.
Plasma NfL Goes the Distance in Alzheimer’s
In ADNI, blood marker exposes ongoing neurodegeneration across disease stages.
ARIAS: Zooming in On Eye-based Biomarkers for Alzheimer’s
Scientists know that the retina changes in people with preclinical AD; alas, there is neither consensus nor convergence in the field of retinal imaging. An upcoming initiative aims to determine which measures are most robust.
Spitting, Sniffing: Is This How We Will Dx Parkinson’s?
Scientists are probing saliva and skin secretions for telltale signs of Parkinson’s disease. Their prize? A diagnostic test at the pre-motor stage.
New Money to Spur Tech Search for AD Biomarkers
Diagnostics Accelerator to fund projects that develop dementia biomarkers from patient data.
Electrode Detects Aβ Aggregates in Alzheimer’s Plasma
The method purportedly distinguishes patients from controls with more than 90 percent sensitivity and specificity.
Results from IDEAS Study Published
A majority of amyloid PET scans led physicians to change how they managed a patient’s disease. The effect on later outcomes is yet to be come.
NIH Summit Sets Agenda for AD-Related Dementias
Among 20 focus areas, 47 research recommendations cover the gamut from basic science to health disparities.
Deep Blue for Aβ Blood Test?
IBM researchers in Australia identify a combination of four proteins in plasma that predicts amyloid positivity in cerebrospinal fluid, and correlates with progression to AD.
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