Midlife Peripheral Inflammation May Drive Later Cognitive Decline
A longitudinal study finds that middle-aged people with the highest levels of inflammation markers in their blood succumb to the greatest cognitive decline over the next 20 years.
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Is a Woman’s Brain More Susceptible to Tau Pathology?
Among cognitively normal people with amyloid plaques, women have more tau tangles in the entorhinal cortex than do men. Does this indicate susceptibility, or resilience?
Panel of Blood Markers Signals Amyloid in Brain
In cognitively normal people, a set of blood proteins may predict whether or not amyloid plaques have deposited in a person’s brain.
Blood Test Granted Breakthrough Status, To Be Tested in Trial
The FDA has prioritized review of C2N’s blood test for amyloid-β. A pivotal clinical trial will correlate the test with amyloid PET scans.
Another Reason to Catch Some Zzzs: Sleep Regulates Tau Release
Studies in mice and humans show that sleep suppresses extracellular tau and slows its spread.
Neurofilament in Blood Foretells Early Onset Alzheimer’s
In familial Alzheimer’s disease, rise in NfL in the blood precedes disease onset by 16 years.
Deadline to Weigh In on New Biomarker Guidance Approaches
Stakeholders have until February 11 to comment on draft FDA guidance for biomarker qualification.
Tau, More than Aβ, Affects Sleep Early in Alzheimer’s
During deep sleep, people with AD pathology, particularly tau tangles, have less low-frequency slow-wave brain activity, which is important for memory consolidation.
Do Alzheimer’s Biomarkers Vary by Race?
The largest study so far to compare brain scans and CSF among African-Americans and Caucasians finds differences, but participant numbers remain small.
New PET Tracer Selectively Lights Up Activated Microglia in Brain
The ligand binds the microglia-specific CSF1 receptor in animal and postmortem studies; human trials are forthcoming.
2018—A Year in Research
This past year, therapeutic antibodies massively reduced brain amyloid, blood tests came into their own, and systems-based approaches transformed the study of gene expression, glial cells, and selective vulnerability.
Could a Blood Test for Tau Diagnose Alzheimer’s Disease?
An ultrasensitive assay picked up elevated concentrations of N-terminal tau fragments in the blood of people with AD.
Autopsy Study Confirms Flortaucipir PET Lights Up Tau Pathology
Case study in early onset AD finds PET ligand tracks regional tau burden.
Neurofilament Light: A Universal Mark of Neurodegeneration
In patients across a range of neurodegenerative diseases, NfL ramps up in the cerebrospinal fluid. Levels are higher in those with worse disease.
Imaging Data Resurrects Abandoned Parkinson’s Gene Therapy
FDG PET revealed the formation of a new functional brain network. It explains clinical improvements noted previously.
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