343579 RESULTS
RESEARCH NEWS 1999-07-07 Research News Findings reported in tomorrow’s issue of Nature raise the tantalizing possibility of using vaccination to prevent or ameliorate Alzheimer’s disease. In the study, by Dale Schenk and colleagues at Elan Pharmaceuticals, PDAPP transgenic mice w
RESEARCH NEWS 1999-06-23 Research News In tomorrow's issue of Nature, Jorge Ghiso and colleagues at New York University, and coworkers at the National Hospital for Neurology and Neurosurgery in London, report that they have found the gene mutation that produces the amyloid i
RESEARCH NEWS 1999-06-23 Research News In tomorrow’s issue of Nature (pp. 784-788), Kun Ping Lu of Harvard Medical School and colleagues report that an enzyme, prolyl isomerase Pin1, binds to phosphorylated tau from Alzheimer’s patients and restores tau’s ability to bind to micro
RESEARCH NEWS 1999-06-22 Research News Neurons taken from the brains of deceased Alzheimer's patients exhibit markers for apoptosis, but little is known about what induces the expression of apoptotic genes. In today’s proceedings of the National Academy of Science, a Univers
RESEARCH NEWS 1999-06-21 Research News Researchers studying the molecular basis of long-term potentiation (LTP) have typically focused on the role of NMDA glutamate receptor, but two papers published in the June 11 issue of Science elucidate the role of the other glutamate recept
RESEARCH NEWS 1999-06-17 Research News A 1997 study indicated that Alzheimer's patients who carried one or both alleles that code for the E4 form of apolipoprotein had more severe neurodegeneration than did patients who carried only alleles coding for the E3 form of the prot
INTERVIEWS 1999-06-15 Interviews ARF: Your work, although concentrating upon pathological states, seems applicable to both normal and disease-related biology. Is there a particular hypothesis which drives your work? KD: When you look at an AD brain at post-mortem, the most obv
COMMUNITY NEWS 1999-06-10 Community News Genetic testing for the ApoE allele should not be used to aid diagnosis of the sporadic form of Alzheimer's disease, concludes a Stanford University biomedical ethics committee. The E4 variant of the ApoE gene elevates a person's
RESEARCH NEWS 1999-06-08 Research News The "cholinergic hypothesis" of cognition places emphasis on the role of cholinergic neurons in the basal forebrain and their projections to cortical areas. This hypothesis is based to a large extent on findings that this system is
RESEARCH NEWS 1999-06-01 Research News Hopes have been raised that drugs which inhibit the proinflammatory COX-2 enzyme could be effective in treating rheumatoid arthritis and perhaps also Alzheimer's disease, which many scientists think is exacerbated by inflammatory respon
COMMENT The final sentences of the Alzheimer Research Forum News Summary leaves the impression that the cause of the disparity is due to differences in the statistical methods used. In fact, this is not at all correct. The Rogaeva et al paper used the SAME family
COMMENT Response from Rudy Tanzi In Peter Hyslop's reply to the Alzheimer Forum News article on "A2M Revisited," he states: "The Rogaeva et al paper used the SAME family based association statistical methods as Blacker et al (ie the SDT and s-
COMMENT Thanks for summarizing the three new A2M genetics papers and our reply in Nature Genetics (May 1999) in your "News" section this month. I wanted to share my thoughts on the controversy regarding the candidacy of A2M as a genetic risk factor for
COMMENT Response from Allen Roses et al. to Tanzi Comment Below please find a short, absolute rebuttal to the comments made by Rudy Tanzi. It is followed by a fairly detailed commentary on each point, including copies of relevant dated correspondence that clarify
RESEARCH NEWS 1999-05-06 Research News Last year Deborah Blacker, Rudolph Tanzi and their colleagues reported finding a strong association between a deletion of exon 18 in the gene for α2 macroglobulin (A2M) and Alzheimer's disease. The odds ratio was 3.56, comparable to the
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